ENSMUSG00000002104


Mus musculus

Features
Gene ID: ENSMUSG00000002104
  
Biological name :Rapsn
  
Synonyms : 43 kDa receptor-associated protein of the synapse / P12672 / Rapsn
  
Possible biological names infered from orthology : Q13702 / receptor associated protein of the synapse
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91035620
Gene end: 91045729
  
Corresponding Affymetrix probe sets: 10473783 (MoGene1.0st)   1449331_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054150
Ensembl peptide - ENSMUSP00000107073
Ensembl peptide - ENSMUSP00000107072
NCBI entrez gene - 19400     See in Manteia.
MGI - MGI:99422
RefSeq - NM_009023
RefSeq - XM_006499017
RefSeq Peptide - NP_033049
swissprot - A2AFX6
swissprot - P12672
swissprot - A2AFX4
Ensembl - ENSMUSG00000002104
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapsnENSDARG00000041133Danio rerio
 RAPSNENSGALG00000008100Gallus gallus
 RAPSNENSG00000165917Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001237  43kDa postsynaptic protein
 IPR001841  Zinc finger, RING-type
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018293  43kDa postsynaptic, conserved site
 IPR019568  Rapsyn, myristoylation/linker region, N-terminal
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IEA
 biological_processGO:1900075 positive regulation of neuromuscular synaptic transmission IEA
 biological_processGO:1901626 regulation of postsynaptic membrane organization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0099634 postsynaptic specialization membrane IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0033130 acetylcholine receptor binding ISO
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0043495 protein membrane anchor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001055 failure of postsynaptic differentiation "inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation" [J:61509]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr