ENSMUSG00000002280


Mus musculus

Features
Gene ID: ENSMUSG00000002280
  
Biological name :Narfl
  
Synonyms : Cytosolic Fe-S cluster assembly factor NARFL / Narfl / Q7TMW6
  
Possible biological names infered from orthology : nuclear prelamin A recognition factor like / Q9H6Q4
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 25773776
Gene end: 25783332
  
Corresponding Affymetrix probe sets: 10442857 (MoGene1.0st)   1450452_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120281
Ensembl peptide - ENSMUSP00000002350
Ensembl peptide - ENSMUSP00000117136
NCBI entrez gene - 67563     See in Manteia.
MGI - MGI:1914813
RefSeq - NM_026238
RefSeq - XM_006524828
RefSeq - XM_006524829
RefSeq Peptide - NP_080514
swissprot - D6RJ43
swissprot - Q7TMW6
Ensembl - ENSMUSG00000002280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 narflENSDARG00000062216Danio rerio
 NARFLENSGALG00000005365Gallus gallus
 NARFLENSG00000103245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Narf / Q9CYQ7 / Nuclear prelamin A recognition factor / Q9UHQ1*ENSMUSG0000000005647


Protein motifs (from Interpro)
Interpro ID Name
 IPR003149  Iron hydrogenase, small subunit
 IPR004108  Iron hydrogenase, large subunit, C-terminal
 IPR009016  Iron hydrogenase
 IPR036991  Iron hydrogenase, small subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016226 iron-sulfur cluster assembly IEA
 biological_processGO:0032364 oxygen homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0097361 CIA complex IEA
 molecular_functionGO:0003954 NADH dehydrogenase activity IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IBA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Artm3.1(AR)Ska/Y,Tg(KLKB1-cre/ERT2)1Pcn/0,Tg(TRAMP)8247Ng/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0006205 embryonic lethality before somite formation "death anytime after implantation but before somite formation (E4.5 to less than E8)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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