ENSMUSG00000002324


Mus musculus

Features
Gene ID: ENSMUSG00000002324
  
Biological name :Rec8
  
Synonyms : Meiotic recombination / Q8C5S7 / Rec8
  
Possible biological names infered from orthology : O95072 / REC8 meiotic recombination protein
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55618037
Gene end: 55625395
  
Corresponding Affymetrix probe sets: 10415332 (MoGene1.0st)   1419147_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002395
NCBI entrez gene - 56739     See in Manteia.
MGI - MGI:1929645
RefSeq - XM_017316099
RefSeq - NM_020002
RefSeq - XM_017316098
RefSeq Peptide - NP_064386
swissprot - Q8C5S7
Ensembl - ENSMUSG00000002324
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rec8aENSDARG00000078329Danio rerio
 rec8bENSDARG00000069260Danio rerio
 REC8ENSG00000100918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006909  Rad21/Rec8-like protein, C-terminal, eukaryotic
 IPR006910  Rad21/Rec8-like protein, N-terminal
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IGI
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion IBA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007130 synaptonemal complex assembly IGI
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0051321 meiotic cell cycle IPI
 biological_processGO:0072520 seminiferous tubule development IGI
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IDA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0000800 lateral element IDA
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0030893 meiotic cohesin complex IDA
 cellular_componentGO:0034991 nuclear meiotic cohesin complex IDA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Rec8mei8/Rec8mei8
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Rec8tm1.1Kktk/Rec8tm1.1Kktk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rec8mei8/Rec8mei8
Genetic Background: B6.Cg-Rec8mei8

Allelic Composition: Rad21ltm1Yow/Rad21ltm1Yow,Rec8mei8/Rec8mei8
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Rec8mei8/Rec8mei8,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxd13tm1Mrc/Hoxd13+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rec8mei8/Rec8mei8,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rec8tm1Mjm/Rec8tm1Mjm
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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