ENSMUSG00000002778


Mus musculus

Features
Gene ID: ENSMUSG00000002778
  
Biological name :Kdelr1
  
Synonyms : KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 / Kdelr1 / Q99JH8
  
Possible biological names infered from orthology : KDEL endoplasmic reticulum protein retention receptor 1 / P24390
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45872772
Gene end: 45883732
  
Corresponding Affymetrix probe sets: 10553131 (MoGene1.0st)   1460211_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002855
Ensembl peptide - ENSMUSP00000148258
Ensembl peptide - ENSMUSP00000147273
NCBI entrez gene - 68137     See in Manteia.
MGI - MGI:1915387
RefSeq - NM_133950
RefSeq Peptide - NP_598711
swissprot - A0A1B0GT97
swissprot - A0A1B0GQW0
swissprot - Q99JH8
Ensembl - ENSMUSG00000002778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KDELR1ENSG00000105438Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdelr2 / Q9CQM2 / KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 / P33947* / KDEL endoplasmic reticulum protein retention receptor 2*ENSMUSG0000007911177
Kdelr3 / Q8R1L4 / KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 / O43731* / KDEL endoplasmic reticulum protein retention receptor 3*ENSMUSG0000001083067


Protein motifs (from Interpro)
Interpro ID Name
 IPR000133  ER lumen protein retaining receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002369 T cell cytokine production IMP
 biological_processGO:0006621 protein retention in ER lumen IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0070231 T cell apoptotic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030663 COPI-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0046923 ER retention sequence binding IEA


Pathways (from Reactome)
Pathway description
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0
Genetic Background: C57BL/6J-Kdelr1em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr
Genetic Background: involves: C57BL/6J * C57BL/6JJcl

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0008041 absent NK T cells "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Srcin1tm1Fdc/Srcin1+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr