ENSMUSG00000002846


Mus musculus

Features
Gene ID: ENSMUSG00000002846
  
Biological name :Timmdc1
  
Synonyms : Complex I assembly factor TIMMDC1, mitochondrial / Q8BUY5 / Timmdc1
  
Possible biological names infered from orthology : Q9NPL8 / translocase of inner mitochondrial membrane domain containing 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B4
Gene start: 38498347
Gene end: 38522663
  
Corresponding Affymetrix probe sets: 10439463 (MoGene1.0st)   1420329_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002925
NCBI entrez gene - 76916     See in Manteia.
MGI - MGI:1922139
RefSeq - NM_024273
RefSeq Peptide - NP_077235
swissprot - Q8BUY5
Ensembl - ENSMUSG00000002846
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timmdc1ENSDARG00000053466Danio rerio
 TIMMDC1ENSGALG00000024480Gallus gallus
 Q9NPL8ENSG00000113845Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Complex I biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gp1baPlt17/Gp1ba+
Genetic Background: involves: BALB/c

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gp1baPlt17/Gp1ba+
Genetic Background: involves: BALB/c

 MP:0013684 increased early germinal center B cell number "increase in the number of germinal center B cells with residual expression of IgD" [MGI:Saran]
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Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0013685 decreased late germinal center B cell number "reduction in the number of germinal center B cells expressing IgG1 and lacking expression of IgD" [MGI:Saran]
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Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000070283 Q9JKL4 / Ndufaf3 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 / Q9BU61* / NADH:ubiquinone oxidoreductase complex assembly factor 3*  / reaction / complex
 ENSMUSG00000050323 A2AIL4 / Ndufaf6 / NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 / Q330K2* / NADH:ubiquinone oxidoreductase complex assembly factor 6*  / reaction / complex
 ENSMUSG00000028261 Q9D1H6 / Ndufaf4 / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 / Q9P032* / NADH:ubiquinone oxidoreductase complex assembly factor 4*  / complex / reaction
 ENSMUSG00000028648 Ndufs5 / Q99LY9 / NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 / O43920* / NADH:ubiquinone oxidoreductase subunit S5*  / reaction / complex
 ENSMUSG00000027384 A2APY7 / Ndufaf5 / Arginine-hydroxylase NDUFAF5, mitochondrial / Q5TEU4* / NADH:ubiquinone oxidoreductase complex assembly factor 5*  / reaction / complex






 

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