ENSMUSG00000003123


Mus musculus

Features
Gene ID: ENSMUSG00000003123
  
Biological name :Lipe
  
Synonyms : Hormone-sensitive lipase / Lipe / P54310
  
Possible biological names infered from orthology : lipase E, hormone sensitive type / Q05469
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25379527
Gene end: 25398710
  
Corresponding Affymetrix probe sets: 10561031 (MoGene1.0st)   1422820_at (Mouse Genome 430 2.0 Array)   1432180_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123485
Ensembl peptide - ENSMUSP00000146000
Ensembl peptide - ENSMUSP00000145669
Ensembl peptide - ENSMUSP00000145665
Ensembl peptide - ENSMUSP00000003207
Ensembl peptide - ENSMUSP00000050935
Ensembl peptide - ENSMUSP00000100811
NCBI entrez gene - 16890     See in Manteia.
MGI - MGI:96790
RefSeq - XM_006539570
RefSeq - XM_006539572
RefSeq - XM_006539571
RefSeq - NM_001039507
RefSeq - NM_010719
RefSeq Peptide - NP_001034596
RefSeq Peptide - NP_034849
swissprot - P54310
swissprot - Q9D4C4
swissprot - E9Q4M2
swissprot - A0A0U1RNR0
swissprot - A0A0U1RPJ0
Ensembl - ENSMUSG00000003123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lipeaENSDARG00000063037Danio rerio
 lipebENSDARG00000101145Danio rerio
 LIPEENSG00000079435Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002168  Lipase, GDXG, putative histidine active site
 IPR010468  Hormone-sensitive lipase, N-terminal
 IPR013094  Alpha/beta hydrolase fold-3
 IPR029058  Alpha/Beta hydrolase fold
 IPR033140  Lipase, GDXG, putative serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter ISS
 biological_processGO:0006363 termination of RNA polymerase I transcription ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019433 triglyceride catabolic process IEA
 biological_processGO:0042758 long-chain fatty acid catabolic process IDA
 biological_processGO:0046340 diacylglycerol catabolic process IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004806 triglyceride lipase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016298 lipase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017171 serine hydrolase activity IDA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0033878 hormone-sensitive lipase activity IEA
 molecular_functionGO:0042134 rRNA primary transcript binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sall1tm1Mrau/Sall1+
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi
Genetic Background: B6.129S7-Lipetm1Ishi

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi
Genetic Background: B6.129S7-Lipetm1Ishi

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall1tm1Mrau/Sall1+
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sall1tm1Mrau/Sall1+
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: B6.129P2-Lipctm1Unc

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ahrtm2Bra/Ahrtm2Bra
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thtm1(cre/Esr1)Nat/Thtm1(cre/Esr1)Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall1tm1Mrau/Sall1+
Genetic Background: involves: 129X1/SvJ * ICR

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi
Genetic Background: B6.129S7-Lipetm1Ishi

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thtm1(cre/Esr1)Nat/Thtm1(cre/Esr1)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129S7-Nceh1tm1Ishi Lipetm1Ishi

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi
Genetic Background: B6.129S7-Lipetm1Ishi

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thtm1(cre/Esr1)Nat/Thtm1(cre/Esr1)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipetm1Ishi/Lipetm1Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipetm1Ishi/Lipetm1Ishi,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thtm1(cre/Esr1)Nat/Thtm1(cre/Esr1)Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129S7-Nceh1tm1Ishi Lipetm1Ishi

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi
Genetic Background: B6.129S7-Lipetm1Ishi

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0008032 abnormal lipolysis "anomaly in the process of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Lipetm2Rze/Lipetm2Rze,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Lipetm1Rze/Lipetm1Rze
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Lipetm1Land/Lipetm1Land
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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