ENSMUSG00000003235


Mus musculus

Features
Gene ID: ENSMUSG00000003235
  
Biological name :Eif2b5
  
Synonyms : Eif2b5 / Q8CHW4 / Translation initiation factor eIF-2B subunit epsilon
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2B subunit epsilon / Q13144
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 20498817
Gene end: 20509955
  
Corresponding Affymetrix probe sets: 10434348 (MoGene1.0st)   1433886_at (Mouse Genome 430 2.0 Array)   1445908_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003320
Ensembl peptide - ENSMUSP00000121169
NCBI entrez gene - 224045     See in Manteia.
MGI - MGI:2446176
RefSeq - NM_172265
RefSeq Peptide - NP_758469
swissprot - F6T9C3
swissprot - Q8CHW4
Ensembl - ENSMUSG00000003235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2b5ENSDARG00000074995Danio rerio
 EIF2B5ENSGALG00000008376Gallus gallus
 EIF2B5ENSG00000145191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001451  Hexapeptide repeat
 IPR003307  W2 domain
 IPR011004  Trimeric LpxA-like superfamily
 IPR016024  Armadillo-type fold
 IPR029044  Nucleotide-diphospho-sugar transferases
 IPR035543  Translation initiation factor eIF-2B subunit epsilon, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation ISO
 biological_processGO:0007568 aging IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035690 cellular response to drug ISO
 biological_processGO:0042552 myelination IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045948 positive regulation of translational initiation ISS
 biological_processGO:0048708 astrocyte differentiation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005851 eukaryotic translation initiation factor 2B complex IEA
 molecular_functionGO:0003743 translation initiation factor activity ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031369 translation initiation factor binding IEA


Pathways (from Reactome)
Pathway description
Recycling of eIF2:GDP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Eif2b5tm1Itl/Eif2b5tm1Itl
Genetic Background: involves: 129S/SvEv

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2b5tm1Itl/Eif2b5tm1Itl
Genetic Background: involves: 129S/SvEv

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2b5tm1Itl/Eif2b5tm1Itl
Genetic Background: involves: 129S/SvEv

 MP:0010160 increased oligodendrocyte number "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc24a4tm1.2Hazh/Slc24a4tm1.2Hazh,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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