ENSMUSG00000003438


Mus musculus

Features
Gene ID: ENSMUSG00000003438
  
Biological name :Timm50
  
Synonyms : Mitochondrial import inner membrane translocase subunit TIM50 / Q9D880 / Timm50
  
Possible biological names infered from orthology : Q3ZCQ8 / translocase of inner mitochondrial membrane 50
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 28305516
Gene end: 28312072
  
Corresponding Affymetrix probe sets: 10561388 (MoGene1.0st)   1441819_x_at (Mouse Genome 430 2.0 Array)   1455456_a_at (Mouse Genome 430 2.0 Array)   1459830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080614
NCBI entrez gene - 66525     See in Manteia.
MGI - MGI:1913775
RefSeq - NM_025616
RefSeq - XM_011250673
RefSeq Peptide - NP_079892
swissprot - Q9D880
Ensembl - ENSMUSG00000003438
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timm50ENSDARG00000031098Danio rerio
 Q3ZCQ8ENSG00000105197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004274  FCP1 homology domain
 IPR023214  HAD superfamily
 IPR027111  Mitochondrial import inner membrane translocase subunit Tim50
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007006 mitochondrial membrane organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030150 protein import into mitochondrial matrix IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005744 mitochondrial inner membrane presequence translocase complex ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005134 interleukin-2 receptor binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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