ENSMUSG00000003526


Mus musculus

Features
Gene ID: ENSMUSG00000003526
  
Biological name :Prodh
  
Synonyms : Prodh / Proline dehydrogenase 1, mitochondrial / Q9WU79
  
Possible biological names infered from orthology : O43272 / proline dehydrogenase 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 18060357
Gene end: 18090203
  
Corresponding Affymetrix probe sets: 10438272 (MoGene1.0st)   1417629_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121736
Ensembl peptide - ENSMUSP00000123223
Ensembl peptide - ENSMUSP00000122889
Ensembl peptide - ENSMUSP00000003620
Ensembl peptide - ENSMUSP00000117597
Ensembl peptide - ENSMUSP00000118264
NCBI entrez gene - 19125     See in Manteia.
MGI - MGI:97770
RefSeq - XM_006521863
RefSeq - NM_011172
RefSeq Peptide - NP_035302
swissprot - F6YFQ5
swissprot - A0A0R4J1T9
swissprot - F6XMC0
swissprot - Q9WU79
swissprot - F6PYI8
swissprot - E9PUR5
Ensembl - ENSMUSG00000003526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prodhaENSDARG00000086746Danio rerio
 prodhbENSDARG00000086512Danio rerio
 ENSGALG00000007728Gallus gallus
 PRODHENSG00000100033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prodh2 / Q8VCZ9 / proline dehydrogenase (oxidase) 2 / Q9UF12* / proline dehydrogenase 2*ENSMUSG0000003689228


Protein motifs (from Interpro)
Interpro ID Name
 IPR002872  Proline dehydrogenase domain
 IPR015659  Proline oxidase family
 IPR029041  FAD-linked oxidoreductase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006560 proline metabolic process IEA
 biological_processGO:0006562 proline catabolic process IEA
 biological_processGO:0010133 proline catabolic process to glutamate IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0004657 proline dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0071949 FAD binding ISO


Pathways (from Reactome)
Pathway description
Proline catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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