ENSMUSG00000004366


Mus musculus

Features
Gene ID: ENSMUSG00000004366
  
Biological name :Sst
  
Synonyms : P60041 / somatostatin / Sst
  
Possible biological names infered from orthology : P61278
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 23889573
Gene end: 23890958
  
Corresponding Affymetrix probe sets: 10438730 (MoGene1.0st)   1417954_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004480
NCBI entrez gene - 20604     See in Manteia.
MGI - MGI:98326
RefSeq - NM_009215
RefSeq Peptide - NP_033241
swissprot - P60041
swissprot - Q545V6
Ensembl - ENSMUSG00000004366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sst1.1ENSDARG00000040799Danio rerio
 SSTENSGALG00000007361Gallus gallus
 SSTENSG00000157005Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004250  Somatostatin
 IPR018142  Somatostatin/Cortistatin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006972 hyperosmotic response IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0048545 response to steroid hormone IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005179 hormone activity IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ptchd1tm2.1Gfng/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1.1Kkan/Npr1tm1.1Kkan,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlx5tm1(cre/ERT2)Zjh/Dlx5+
Genetic Background: C57BL/6-Dlx5tm1(cre/ERT2)Zjh

Allelic Composition: Ssttm2.1(cre)Zjh/Ssttm2.1(cre)Zjh
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ssttm3.1(flpo)Zjh/Ssttm3.1(flpo)Zjh
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002911 abnormal inhibitory postsynaptic potential "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003795 abnormal bone structure 
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003892 abnormal gastric gland "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrocholric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004731 increased circulating gastrin level "greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0005116 abnormal circulating pituitary hormone level "aberration in the blood concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0008002 hyperchlorhydria "increased hydrochloric acid content of the gastric secretions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Lcs/Gast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010778 abnormal stomach fundus morphology "any structural anomaly of the region of the stomach that lies above the cardiac notch that functions to store undigested food and to collect stomach gases produced by chemical digestion" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Lcs/Gast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011612 increased circulating ghrelin level "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
Show

Allelic Composition: Atp4am1Btlr/Atp4am1Btlr
Genetic Background: involves: C57BL/6J

 MP:0014114 abnormal cognition "any anomaly in the operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory" [GO:0050890]
Show

Allelic Composition: Ptchd1tm2.1Gfng/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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