ENSMUSG00000004473


Mus musculus

Features
Gene ID: ENSMUSG00000004473
  
Biological name :Clec11a
  
Synonyms : Clec11a / C-type lectin domain family 11 member A / O88200
  
Possible biological names infered from orthology : C-type lectin domain containing 11A / Q9Y240
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44302687
Gene end: 44306902
  
Corresponding Affymetrix probe sets: 10562761 (MoGene1.0st)   1418796_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004587
NCBI entrez gene - 20256     See in Manteia.
MGI - MGI:1298219
RefSeq - NM_009131
RefSeq Peptide - NP_033157
swissprot - O88200
Ensembl - ENSMUSG00000004473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clec11aENSDARG00000079107Danio rerio
 Q9Y240ENSG00000105472Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec3a / Q9EPW4 / C-type lectin domain family 3 member A ENSMUSG0000000887416
Clec3b / C-type lectin domain family 3, member b / P05452*ENSMUSG0000002578413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008083 growth factor activity ISO
 molecular_functionGO:0030246 carbohydrate binding NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0013624 decreased femur compact bone thickness "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0013633 decreased femur maximal load "decrease in the maximal load (N) sustained by the femur" [MGI:jwhite]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0013646 decreased energy dissipated prior to femur fracture "decrease in the fraction of total energy dissapated prior to ultimate material failure (high energy fracture) by the femur" [MGI:jwhite]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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