ENSMUSG00000004988


Mus musculus

Features
Gene ID: ENSMUSG00000004988
  
Biological name :Fxyd4
  
Synonyms : Fxyd4 / FXYD domain-containing ion transport regulator 4 / Q9D2W0
  
Possible biological names infered from orthology : P59646
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 117933559
Gene end: 117937692
  
Corresponding Affymetrix probe sets: 10547206 (MoGene1.0st)   1418207_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145293
Ensembl peptide - ENSMUSP00000145182
Ensembl peptide - ENSMUSP00000145302
Ensembl peptide - ENSMUSP00000005114
Ensembl peptide - ENSMUSP00000144700
Ensembl peptide - ENSMUSP00000144773
NCBI entrez gene - 108017     See in Manteia.
MGI - MGI:1889005
RefSeq - XM_017321297
RefSeq - XM_006505294
RefSeq - XM_006505295
RefSeq - XM_011241112
RefSeq - XM_011241113
RefSeq - XM_011241114
RefSeq - NM_001173372
RefSeq - NM_033648
RefSeq - XM_006505290
RefSeq Peptide - NP_001166843
RefSeq Peptide - NP_387468
swissprot - A0A0N4SVY0
swissprot - Q9D2W0
swissprot - A0A0N4SVN7
Ensembl - ENSMUSG00000004988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FXYD4ENSG00000150201Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fxyd3 / Q61835 / FXYD domain-containing ion transport regulator 3 / Q14802*ENSMUSG0000005709257


Protein motifs (from Interpro)
Interpro ID Name
 IPR000272  Ion-transport regulator, FXYD motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IBA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002847 abnormal glomerular filtration rate "deviation from the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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