ENSMUSG00000005362


Mus musculus

Features
Gene ID: ENSMUSG00000005362
  
Biological name :Crbn
  
Synonyms : Crbn / Protein cereblon / Q8C7D2
  
Possible biological names infered from orthology : cereblon / Q96SW2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E1
Gene start: 106780201
Gene end: 106800077
  
Corresponding Affymetrix probe sets: 10546775 (MoGene1.0st)   1423094_at (Mouse Genome 430 2.0 Array)   1423095_s_at (Mouse Genome 430 2.0 Array)   1455734_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144723
Ensembl peptide - ENSMUSP00000013882
Ensembl peptide - ENSMUSP00000108865
NCBI entrez gene - 58799     See in Manteia.
MGI - MGI:1913277
RefSeq - NM_021449
RefSeq - NM_175357
RefSeq Peptide - NP_067424
RefSeq Peptide - NP_780566
swissprot - A0A0N4SUK9
swissprot - Q8C7D2
Ensembl - ENSMUSG00000005362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crbnENSDARG00000054250Danio rerio
 CRBNENSGALG00000008274Gallus gallus
 CRBNENSG00000113851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003111  Lon, substrate-binding domain
 IPR004910  Yippee/Mis18/Cereblon
 IPR015947  PUA-like superfamily
 IPR034750  CULT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0032463 negative regulation of protein homooligomerization IEA
 biological_processGO:0034766 negative regulation of ion transmembrane transport IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdpd5tm1.1Itl/Gdpd5tm1.1Itl,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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