ENSMUSG00000006235


Mus musculus

Features
Gene ID: ENSMUSG00000006235
  
Biological name :Epor
  
Synonyms : Epor / Erythropoietin receptor / P14753
  
Possible biological names infered from orthology : P19235
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21958897
Gene end: 21963506
  
Corresponding Affymetrix probe sets: 10591660 (MoGene1.0st)   1423344_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006397
Ensembl peptide - ENSMUSP00000149402
NCBI entrez gene - 13857     See in Manteia.
MGI - MGI:95408
RefSeq - XM_017313130
RefSeq - NM_010149
RefSeq - XM_006509998
RefSeq Peptide - NP_034279
swissprot - P14753
swissprot - Q3UTV9
swissprot - A0A1L1SRC0
Ensembl - ENSMUSG00000006235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eporENSDARG00000090834Danio rerio
 EPORENSG00000187266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mpl / Q08351 / Thrombopoietin receptor / P40238* / MPL proto-oncogene, thrombopoietin receptor*ENSMUSG0000000638914


Protein motifs (from Interpro)
Interpro ID Name
 IPR003528  Long hematopoietin receptor, single chain, conserved site
 IPR003961  Fibronectin type III
 IPR009167  Erythropoietin receptor
 IPR013783  Immunoglobulin-like fold
 IPR015152  Growth hormone/erythropoietin receptor, ligand binding
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0038162 erythropoietin-mediated signaling pathway IEA
 biological_processGO:0046697 decidualization IDA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis TAS
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis TAS
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0061032 visceral serous pericardium development TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004900 erythropoietin receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lattm2.1Lov/Lattm2.1Lov
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Eportm2Jni/Eportm2Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Eportm1Jni/Eportm1Jni
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Eportm2Jni/Eportm2Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyrk3tm1Dowo/Dyrk3tm1Dowo,Eportm2Jni/Eportm2Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Eedtm1Sho/Eedtm1Sho,Eportm1(EGFP/cre)Uk/Epor+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Eportm1Jae/Epor+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0001711 abnormal placenta 
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Itgb1tm1Lscd/Itgb1tm1Lscd
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Eportm1.4Jtp/Epor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Eportm1Jni/Eportm1Jni
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Eportm1.4Jtp/Epor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Kdm1atm1.1Sho/Kdm1a+,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0004032 abnormal interventricular groove "malformation of the intendation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm2.1Lov/Lattm2.1Lov
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Eportm1.4Jtp/Epor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20m2Btlr/Adamts20m2Btlr
Genetic Background: C57BL/6J-Adamts20m2Btlr

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Eportm1Jae/Eportm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lattm2.1Lov/Lattm2.1Lov
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Eportm1.3Jtp/Eportm1.3Jtp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011243 decreased fetal derived definitive erythrocyte cell number "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515]
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Allelic Composition: Kdm1atm1.1Sho/Kdm1atm1.1Sho,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129 * BALB/cJ

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129 * BALB/cJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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