ENSMUSG00000006782


Mus musculus

Features
Gene ID: ENSMUSG00000006782
  
Biological name :Cnp
  
Synonyms : 2,3-cyclic-nucleotide 3-phosphodiesterase / Cnp / P16330
  
Possible biological names infered from orthology : P09543
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 100574904
Gene end: 100591729
  
Corresponding Affymetrix probe sets: 10381154 (MoGene1.0st)   1418980_a_at (Mouse Genome 430 2.0 Array)   1437341_x_at (Mouse Genome 430 2.0 Array)   1449296_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099409
NCBI entrez gene - 12799     See in Manteia.
MGI - MGI:88437
RefSeq - XM_017314245
RefSeq - NM_001146318
RefSeq - NM_009923
RefSeq Peptide - NP_034053
RefSeq Peptide - NP_001139790
swissprot - P16330
swissprot - Q3TYV5
Ensembl - ENSMUSG00000006782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnpENSDARG00000070822Danio rerio
 CNPENSGALG00000003457Gallus gallus
 CNPENSG00000173786Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008431  Cyclic nucleotide phosphodiesterase
 IPR009097  Cyclic phosphodiesterase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009214 cyclic nucleotide catabolic process IEA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0035749 myelin sheath adaxonal region IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004113 2",3"-cyclic-nucleotide 3"-phosphodiesterase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030551 cyclic nucleotide binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Fa2htm1Hama/Fa2htm1Hama,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129 * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fa2htm1Hama/Fa2htm1Hama,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129 * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm3Cbm,Erbb4tm1Fej/Erbb4tm1Fej,Cnptm1(cre)Kan/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001105 abnormal PNS glia "malformation or absence of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm2Bhat/Nfasctm2Bhat,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm2Bhat/Nfasctm2Bhat,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fa2htm1Hama/Fa2htm1Hama,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129 * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm2Bhat/Nfasctm2Bhat,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fa2htm1Hama/Fa2htm1Hama,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129 * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aurkatm1.2Tvd/Aurkatm1.2Tvd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdm4btm1.2Okad/Kdm4btm1.2Okad
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myrftm1Barr/Myrftm1Barr,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aurkatm1.2Tvd/Aurkatm1.2Tvd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fa2htm1Hama/Fa2htm1Hama,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129 * C57BL/6

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003647 absent oligodendrocytes "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Asah1tm1.1Jhkh/Asah1+,Smpd1tm1Esc/Smpd1+
Genetic Background: involves: 129S1/Sv

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cnptm1(cre)Kan/Cnptm1(cre)Kan
Genetic Background: B6N.129-Cnptm1(cre)Kan

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Sept8tm1c(EUCOMM)Wtsi/Sept8tm1c(EUCOMM)Wtsi
Genetic Background: B6N.Cg-Sept8tm1c(EUCOMM)Wtsi Cnptm1(cre)Kan

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010734 abnormal paranode morphology "any structural anomaly of the axon region immediately adjacent to nodes of Ranvier, where a series of cytoplasmic loops from the overlying glial cell form septate-like junctions with the axon; the axoglial junctions act as a diffusion barrier between the node and internode" [PMID:16224497]
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Allelic Composition: Nfasctm2Bhat/Nfasctm2Bhat,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010735 abnormal paranodal axoglial junction morphology "any structural anomaly of the structure in which the myelin sheath attaches to the axon at each end of each myelin segment; the axoglial junctions act as a diffusion barrier between the node and internode, maintaining domain-specific axolemmal membrane components" [PMID:19224642]
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Allelic Composition: Nfasctm2Bhat/Nfasctm2Bhat,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010738 abnormal internode morphology "any structrual anomaly of the intervening axon segment that is located between the juxtaparanodes and is surrounded by a single compact myelin sheath" [PMID:18929652]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010739 abnormal axolemma morphology "any structural anomaly of the plasma membrane of an axon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mtortm1Koz/Mtortm1Koz,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010742 increased Schwann cell number "greater than normal number of cells that sheath the axons of the peripheral nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drp2tm1.1Brp/Y,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Erbb3tm2Cbm/Erbb3tm3Cbm,Erbb4tm1Fej/Erbb4tm1Fej,Cnptm1(cre)Kan/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Nfasctm1Bhat/Nfasctm1Bhat,Cnptm1(cre)Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Myrftm1Barr/Myrftm1Barr,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012674 tomacula "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Sept8tm1c(EUCOMM)Wtsi/Sept8tm1c(EUCOMM)Wtsi
Genetic Background: B6N.Cg-Sept8tm1c(EUCOMM)Wtsi Cnptm1(cre)Kan

Allelic Composition: Cnptm1(cre)Kan/Cnptm1(cre)Kan
Genetic Background: B6N.129-Cnptm1(cre)Kan

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Cnptm1(cre)Kan/Cnptm1(cre)Kan
Genetic Background: B6N.129-Cnptm1(cre)Kan

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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