ENSMUSG00000007035


Mus musculus

Features
Gene ID: ENSMUSG00000007035
  
Biological name :Msh5
  
Synonyms : Msh5
  
Possible biological names infered from orthology : MSH5-SAPCD1 / MSH5-SAPCD1 readthrough (NMD candidate) / mutS homolog 5 / O43196
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35028605
Gene end: 35046745
  
Corresponding Affymetrix probe sets: 10450384 (MoGene1.0st)   1430771_a_at (Mouse Genome 430 2.0 Array)   1449537_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134426
Ensembl peptide - ENSMUSP00000134065
Ensembl peptide - ENSMUSP00000134295
Ensembl peptide - ENSMUSP00000007250
Ensembl peptide - ENSMUSP00000094951
Ensembl peptide - ENSMUSP00000133415
Ensembl peptide - ENSMUSP00000134061
NCBI entrez gene - 17687     See in Manteia.
MGI - MGI:1329021
RefSeq - XM_017317286
RefSeq - XM_017317278
RefSeq - XM_017317279
RefSeq - XM_017317280
RefSeq - XM_017317281
RefSeq - XM_017317282
RefSeq - XM_017317283
RefSeq - XM_017317284
RefSeq - XM_017317285
RefSeq - NM_001146215
RefSeq - NM_013600
RefSeq - XM_006523770
RefSeq - XM_006523771
RefSeq - XM_006523778
RefSeq - XM_006523780
RefSeq - XM_011246314
RefSeq Peptide - NP_038628
RefSeq Peptide - NP_001139687
swissprot - G3UZ06
swissprot - G3UZB5
swissprot - G3UYF3
swissprot - A0A0R4IZY8
swissprot - G3UWT5
swissprot - G3UYF6
Ensembl - ENSMUSG00000007035
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh5ENSDARG00000077479Danio rerio
 ENSGALG00000038188Gallus gallus
 MSH5ENSG00000204410Homo sapiens
 MSH5-SAPCD1ENSG00000255152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR011184  DNA mismatch repair Msh2-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036187  DNA mismatch repair protein MutS, core domain superfamily
 IPR036678  MutS, connector domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006298 mismatch repair IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Pafah1b1tm2Awb/Pafah1b1tm2Awb
Genetic Background: involves: 129S/SvEv * FVB/N * NIH Black Swiss

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Msh5tm1Htr/Msh5tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0013236 ovary degeneration "a retrogressive impairment of function or destruction of one or both ovaries" [MGI:anna]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0013605 abnormal ovarian bursa morphology "any structural anomaly of the peritoneal recess between the medial aspect of the ovary and the mesosalpinx" [MGI:Anna, UBERON:0012333]
Show

Allelic Composition: Msh6tm1Rak/Msh6tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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