ENSMUSG00000008690


Mus musculus

Features
Gene ID: ENSMUSG00000008690
  
Biological name :Ncaph2
  
Synonyms : Ncaph2 / non-SMC condensin II complex, subunit H2 / Q8BSP2
  
Possible biological names infered from orthology : Q6IBW4
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 89355719
Gene end: 89372826
  
Corresponding Affymetrix probe sets: 10426225 (MoGene1.0st)   1423698_at (Mouse Genome 430 2.0 Array)   1423699_at (Mouse Genome 430 2.0 Array)   1429477_at (Mouse Genome 430 2.0 Array)   1439360_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122118
Ensembl peptide - ENSMUSP00000036900
Ensembl peptide - ENSMUSP00000074139
Ensembl peptide - ENSMUSP00000086095
NCBI entrez gene - 52683     See in Manteia.
MGI - MGI:1289164
RefSeq - XM_006521150
RefSeq - NM_001115132
RefSeq - NM_001271600
RefSeq - NM_001271601
RefSeq - XM_006521149
RefSeq Peptide - NP_001108604
RefSeq Peptide - NP_001258529
RefSeq Peptide - NP_001258530
swissprot - E9PY48
swissprot - Q8BSP2
swissprot - D6RGR7
Ensembl - ENSMUSG00000008690
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncaph2ENSDARG00000033757Danio rerio
 ENSGALG00000034272Gallus gallus
 ENSGALG00000013811Gallus gallus
 NCAPH2ENSG00000025770Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm7535 / NCAPH2* / Q6IBW4* / non-SMC condensin II complex subunit H2*ENSMUSG0000009095747


Protein motifs (from Interpro)
Interpro ID Name
 IPR009378  Condensin II complex subunit H2, N-terminal
 IPR031719  Condensin II complex subunit H2, middle domain
 IPR031737  Condensin-2 complex subunit H2, C-terminal
 IPR031739  Condensin-2 complex subunit H2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0000796 condensin complex IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0045171 intercellular bridge ISO


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ncaph2nes/Ncaph2nes,Tg(TcrHEL3A9)1Mmd/0
Genetic Background: C57BL/6-Ncaph2nes Tg(TcrHEL3A9)1Mmd

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ncaph2nes/Ncaph2nes,Tg(TcrHEL3A9)1Mmd/0
Genetic Background: C57BL/6-Ncaph2nes Tg(TcrHEL3A9)1Mmd

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
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Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ncaph2nes/Ncaph2nes,Tg(TcrHEL3A9)1Mmd/0
Genetic Background: C57BL/6-Ncaph2nes Tg(TcrHEL3A9)1Mmd

 MP:0008830 abnormal nucleolus morphology "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Slc2a4tm1Jdz/Slc2a4tm1Jdz,Tg(ACTA1-cre)1Jdz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

 MP:0012203 abnormal neuronal stem cell morphology "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

Allelic Composition: Ncaphtm1.1Itl/Ncaphtm1.2Itl,Ncaph2tm1.1Itl/Ncaph2tm1.2Itl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0012204 abnormal neuronal stem cell physiology "any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
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Allelic Composition: Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.B6-Mcph1Tg(HLA-A2.1)1Enge

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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