ENSMUSG00000009633


Mus musculus

Features
Gene ID: ENSMUSG00000009633
  
Biological name :G0s2
  
Synonyms : G0/G1 switch protein 2 / G0s2 / Q61585
  
Possible biological names infered from orthology : G0/G1 switch 2 / P27469
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 193272161
Gene end: 193273217
  
Corresponding Affymetrix probe sets: 10361246 (MoGene1.0st)   1448700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009777
NCBI entrez gene - 14373     See in Manteia.
MGI - MGI:1316737
RefSeq - NM_008059
RefSeq Peptide - NP_032085
swissprot - Q545U0
swissprot - Q61585
Ensembl - ENSMUSG00000009633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 G0S2ENSGALG00000023933Gallus gallus
 G0S2ENSG00000123689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016821  G0/G1 switch protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0010046 decreased omental fat pad weight "less than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0011581 increased triglyceride lipase activity "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion" [GO:0004806]
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Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
Show

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0014146 decreased white adipose tissue mass "decreasd physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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