ENSMUSG00000009646


Mus musculus

Features
Gene ID: ENSMUSG00000009646
  
Biological name :Pla2g12b
  
Synonyms : phospholipase A2 group XIIB / Pla2g12b
  
Possible biological names infered from orthology : Q9BX93
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 59403660
Gene end: 59421976
  
Corresponding Affymetrix probe sets: 10363372 (MoGene1.0st)   1419614_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009790
Ensembl peptide - ENSMUSP00000123842
NCBI entrez gene - 69836     See in Manteia.
MGI - MGI:1917086
RefSeq - XM_006514062
RefSeq - NM_023530
RefSeq - XM_006514061
RefSeq Peptide - NP_076019
swissprot - Q8VC81
swissprot - F6UTM6
Ensembl - ENSMUSG00000009646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g12bENSDARG00000015662Danio rerio
 PLA2G12BENSGALG00000004332Gallus gallus
 Q9BX93ENSG00000138308Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EPR2 / Pla2g12a / Group XIIA secretory phospholipase A2 / Q9BZM1* / phospholipase A2 group XIIA*ENSMUSG0000002799941


Protein motifs (from Interpro)
Interpro ID Name
 IPR010711  Group XII secretory phospholipase A2 precursor
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pla2g12bmpc96H/Pla2g12bmpc96H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pla2g12bmpc96H/Pla2g12bmpc96H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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