ENSMUSG00000009828


Mus musculus

Features
Gene ID: ENSMUSG00000009828
  
Biological name :Ick
  
Synonyms : Ick / Q9JKV2 / Serine/threonine-protein kinase ICK
  
Possible biological names infered from orthology : intestinal cell kinase / Q9UPZ9
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 78109192
Gene end: 78172107
  
Corresponding Affymetrix probe sets: 10587299 (MoGene1.0st)   1448310_at (Mouse Genome 430 2.0 Array)   1454243_at (Mouse Genome 430 2.0 Array)   1455687_at (Mouse Genome 430 2.0 Array)   1457165_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048234
Ensembl peptide - ENSMUSP00000113655
Ensembl peptide - ENSMUSP00000115522
Ensembl peptide - ENSMUSP00000009972
Ensembl peptide - ENSMUSP00000112961
NCBI entrez gene - 56542     See in Manteia.
MGI - MGI:1934157
RefSeq - XM_006511305
RefSeq - NM_001163780
RefSeq - NM_019987
RefSeq - XM_006511304
RefSeq Peptide - NP_064371
RefSeq Peptide - NP_001157252
swissprot - Q3UZZ3
swissprot - Q9D7Q7
swissprot - Q9JKV2
swissprot - D3YZV1
Ensembl - ENSMUSG00000009828
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ICKENSGALG00000016321Gallus gallus
 ICKENSG00000112144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mak / Q04859 / Serine/threonine-protein kinase MAK / P20794* / male germ cell associated kinase*ENSMUSG0000002136354
Mok / Q9WVS4 / MAPK/MAK/MRK overlapping kinase / Q9UQ07* / MOK protein kinase*ENSMUSG0000005645822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0035720 intraciliary anterograde transport IMP
 biological_processGO:0035721 intraciliary retrograde transport IMP
 biological_processGO:0042073 intraciliary transport IMP
 biological_processGO:0060271 cilium assembly ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097542 ciliary tip IMP
 cellular_componentGO:0097546 ciliary base IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

 MP:0013203 abnormal primary cilium morphology "any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]
Show

Allelic Composition: Mybpc3DBA/2J/Mybpc3DBA/2J,Myh7DBA/2J/Myh7DBA/2J
Genetic Background: DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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