ENSMUSG00000010057


Mus musculus

Features
Gene ID: ENSMUSG00000010057
  
Biological name :Nprl2
  
Synonyms : GATOR complex protein NPRL2 / Nprl2 / Q9WUE4
  
Possible biological names infered from orthology : NPR2 like, GATOR1 complex subunit / Q8WTW4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107542226
Gene end: 107545706
  
Corresponding Affymetrix probe sets: 10588642 (MoGene1.0st)   1417046_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010201
Ensembl peptide - ENSMUSP00000141746
NCBI entrez gene - 56032     See in Manteia.
MGI - MGI:1914482
RefSeq - XM_011242898
RefSeq - NM_018879
RefSeq - XM_006511768
RefSeq - XM_006511769
RefSeq - XM_011242897
RefSeq Peptide - NP_061367
swissprot - Q9WUE4
swissprot - A0A0A6YWX8
Ensembl - ENSMUSG00000010057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nprl2ENSDARG00000059613Danio rerio
 NPRL2ENSGALG00000002131Gallus gallus
 NPRL2ENSG00000114388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009348  Nitrogen permease regulator 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0010508 positive regulation of autophagy IBA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:2000785 regulation of autophagosome assembly IBA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005773 vacuole IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:1990130 GATOR1 complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005096 GTPase activator activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0013242 abnormal amino acid metabolism "any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0013708 abnormal hematopoietic precursor cell number "anomaly in the number of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [CL:0008001]
Show

Allelic Composition: Hfe2tm1Nca/Hfe2tm1Nca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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