ENSMUSG00000010554


Mus musculus

Features
Gene ID: ENSMUSG00000010554
  
Biological name :Mettl16
  
Synonyms : Mettl16 / Q9CQG2 / U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
  
Possible biological names infered from orthology : methyltransferase like 16 / Q86W50
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 74770830
Gene end: 74828525
  
Corresponding Affymetrix probe sets: 10378482 (MoGene1.0st)   1439536_at (Mouse Genome 430 2.0 Array)   1453983_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010698
Ensembl peptide - ENSMUSP00000090590
Ensembl peptide - ENSMUSP00000114682
Ensembl peptide - ENSMUSP00000122272
NCBI entrez gene - 67493     See in Manteia.
MGI - MGI:1914743
RefSeq - XM_017314719
RefSeq - NM_026197
RefSeq - XM_006533998
RefSeq - XM_006533999
RefSeq - XM_006534000
RefSeq - XM_006534001
RefSeq Peptide - NP_080473
swissprot - F8WHZ7
swissprot - Q5SW13
swissprot - Q5SW15
swissprot - Q9CQG2
Ensembl - ENSMUSG00000010554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mettl16ENSDARG00000055838Danio rerio
 Q5ZIA0ENSGALG00000014901Gallus gallus
 Q86W50ENSG00000127804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010286  Ribosomal RNA large subunit methyltransferase F-like
 IPR017182  Methyltransferase METTL16/PsiM
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001510 RNA methylation IDA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006402 mRNA catabolic process IDA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome ISO
 biological_processGO:0061157 mRNA destabilization IDA
 biological_processGO:0070475 rRNA base methylation IBA
 biological_processGO:0080009 mRNA methylation IEA
 biological_processGO:0120049 snRNA (adenine-N6)-methylation IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016422 mRNA (2"-O-methyladenosine-N6-)-methyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030629 U6 snRNA 3"-end binding IEA
 molecular_functionGO:0035613 RNA stem-loop binding IEA
 molecular_functionGO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
 molecular_functionGO:0120048 U6 snRNA (adenine-(43)-N(6))-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Memo1tm1b(EUCOMM)Wtsi/Memo1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Memo1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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