ENSMUSG00000011658


Mus musculus

Features
Gene ID: ENSMUSG00000011658
  
Biological name :Fuz
  
Synonyms : Fuz / fuzzy planar cell polarity protein / Q3UYI6
  
Possible biological names infered from orthology : Q9BT04
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44896079
Gene end: 44902631
  
Corresponding Affymetrix probe sets: 10552779 (MoGene1.0st)   1431025_at (Mouse Genome 430 2.0 Array)   1438749_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071194
Ensembl peptide - ENSMUSP00000147169
Ensembl peptide - ENSMUSP00000147105
Ensembl peptide - ENSMUSP00000146977
Ensembl peptide - ENSMUSP00000146820
Ensembl peptide - ENSMUSP00000146768
Ensembl peptide - ENSMUSP00000146725
Ensembl peptide - ENSMUSP00000146696
Ensembl peptide - ENSMUSP00000146681
Ensembl peptide - ENSMUSP00000146434
Ensembl peptide - ENSMUSP00000146404
NCBI entrez gene - 70300     See in Manteia.
MGI - MGI:1917550
RefSeq - XM_006541191
RefSeq - XM_006541194
RefSeq - NM_027376
RefSeq - XM_006541192
RefSeq - XM_006541193
RefSeq Peptide - NP_081652
swissprot - A0A140LI68
swissprot - A0A140LI55
swissprot - E9QL29
swissprot - Q3UYI6
swissprot - A0A140LHG6
swissprot - A0A140LJD3
swissprot - A0A140LJ73
swissprot - A0A140LIV8
swissprot - A0A140LIH3
swissprot - A0A140LIC9
swissprot - A0A140LI92
Ensembl - ENSMUSG00000011658
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU693445.1ENSDARG00000079730Danio rerio
 FUZENSG00000010361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026069  Fuzzy protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001843 neural tube closure ISO
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0010954 positive regulation of protein processing IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0045724 positive regulation of cilium assembly IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090301 negative regulation of neural crest formation IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 biological_processGO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000457 maxilla hypoplasia "arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Dnah11b2b1279Clo/Dnah11b2b1279Clo
Genetic Background: C57BL/6J-Dnah11b2b1279Clo

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0000927 small floor plate "reduced size of the floor plate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smtntm2Gve/Smtntm2Gve
Genetic Background: B6.129-Smtntm2Gve

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0003817 abnormal Rathke s pouch "malformation or incomplete differentiation of a pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0006130 pulmonary valve atresia "congenital closure of the pulmonary valve" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0008480 absent eye pigmentation "absence of melanin (pigment) in the eye either due to absent melanocytes or failure of melanin synthesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011674 multiple major aortopulmonary collateral arteries 
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
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Allelic Composition: Fuzb2b1273Clo/Fuzb2b1273Clo
Genetic Background: C57BL/6J-Fuzb2b1273Clo

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0030373 Meckel s cartilage hyperplasia "overdevelopment or increased size, usually due to an increased number of cells, of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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