ENSMUSG00000014226


Mus musculus

Features
Gene ID: ENSMUSG00000014226
  
Biological name :Cacybp
  
Synonyms : Cacybp / Calcyclin-binding protein / Q9CXW3
  
Possible biological names infered from orthology : Q9HB71
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.1
Gene start: 160202367
Gene end: 160212875
  
Corresponding Affymetrix probe sets: 10359334 (MoGene1.0st)   1452047_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142252
Ensembl peptide - ENSMUSP00000014370
NCBI entrez gene - 12301     See in Manteia.
MGI - MGI:1270839
RefSeq - NM_009786
RefSeq Peptide - NP_033916
swissprot - A0A0A6YY29
swissprot - Q9CXW3
Ensembl - ENSMUSG00000014226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacybpENSDARG00000014731Danio rerio
 CACYBPENSGALG00000004554Gallus gallus
 CACYBPENSG00000116161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007052  CS domain
 IPR007699  SGS domain
 IPR008978  HSP20-like chaperone
 IPR015120  Siah interacting protein, N-terminal
 IPR037201  Calcyclin-binding protein, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005641 nuclear envelope lumen IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IMP
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044548 S100 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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