ENSMUSG00000014426


Mus musculus

Features
Gene ID: ENSMUSG00000014426
  
Biological name :Map3k4
  
Synonyms : Map3k4 / Mitogen-activated protein kinase kinase kinase 4 / O08648
  
Possible biological names infered from orthology : Q9Y6R4
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 12227621
Gene end: 12318660
  
Corresponding Affymetrix probe sets: 10447742 (MoGene1.0st)   1421450_a_at (Mouse Genome 430 2.0 Array)   1447667_x_at (Mouse Genome 430 2.0 Array)   1450253_a_at (Mouse Genome 430 2.0 Array)   1459800_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086459
NCBI entrez gene - 26407     See in Manteia.
MGI - MGI:1346875
RefSeq - NM_011948
RefSeq - XM_006523329
RefSeq Peptide - NP_036078
swissprot - O08648
Ensembl - ENSMUSG00000014426
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k4ENSDARG00000104835Danio rerio
 MAP3K4ENSGALG00000020003Gallus gallus
 MAP3K4ENSG00000085511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019100 male germ-line sex determination IMP
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0048263 determination of dorsal identity ISO
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060718 chorionic trophoblast cell differentiation IMP
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k4tm1Glj/Map3k4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Map3k4tm1Glj/Map3k4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Map3k4tm1Flv/Map3k4tm1Flv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k4tm1Glj/Map3k4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Del(17)Thp/Map3k4byg
Genetic Background: involves: AKR/J * C3H/HeH * C57BL/6J

Allelic Composition: Map3k4byg/Map3k4tm1Flv
Genetic Background: involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Nr5a1tm1Klp/Nr5a1tm2Klp
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0002212 abnormal secondary sex determination "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0002213 true hermaphroditism "having both ovarian and testicular tissue present" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Del(17)Thp/Map3k4byg
Genetic Background: involves: AKR/J * C3H/HeH * C57BL/6J

Allelic Composition: Map3k4byg/Map3k4tm1Flv
Genetic Background: involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J

Allelic Composition: Map3k4tm1Flv/Map3k4tm1Flv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0002996 ovotestis "gonad with both ovarian and testicular tissue" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Map3k4tm1Glj/Map3k4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
Show

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Gadd45gtm1Jni/Gadd45g+,Map3k4tm1Flv/Map3k4+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0005652 sex reversal "development of the reproductive system is inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0006418 abnormal testis cord formation "any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Del(17)Thp/Map3k4byg
Genetic Background: involves: AKR/J * C3H/HeH * C57BL/6J

 MP:0006424 absent testis cords "missing the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [J:104330, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k4tm1Glj/Map3k4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Slamf1tm1Cpt/Slamf1tm1Cpt,Tg(DO11.10)10Dlo/Tg(DO11.10)10Dlo
Genetic Background: involves: BALB/c * C3H * C57BL/6

Allelic Composition: Map3k4tm1Glj/Map3k4tm1Glj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Map3k4byg/Map3k4byg
Genetic Background: involves: C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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