ENSMUSG00000014771


Mus musculus

Features
Gene ID: ENSMUSG00000014771
  
Biological name :Pdcd2
  
Synonyms : Pdcd2 / programmed cell death 2
  
Possible biological names infered from orthology : Q16342
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A2
Gene start: 15519208
Gene end: 15527301
  
Corresponding Affymetrix probe sets: 10448055 (MoGene1.0st)   1423534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052523
Ensembl peptide - ENSMUSP00000118625
NCBI entrez gene - 18567     See in Manteia.
MGI - MGI:104643
RefSeq - NM_008799
RefSeq Peptide - NP_032825
swissprot - A2T4N6
swissprot - A0A0R4J0N5
Ensembl - ENSMUSG00000014771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdcd2ENSDARG00000007892Danio rerio
 PDCD2ENSGALG00000011169Gallus gallus
 PDCD2ENSG00000071994Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdcd2l / Q8C5N5 / Programmed cell death protein 2-like / Q9BRP1* / AC092073.1* / programmed cell death 2 like*ENSMUSG0000000263527


Protein motifs (from Interpro)
Interpro ID Name
 IPR002893  Zinc finger, MYND-type
 IPR007320  Programmed cell death protein 2, C-terminal
 IPR035948  YwqG-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IEA
 biological_processGO:1902035 positive regulation of hematopoietic stem cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cldn4tm1.1Jhou/Cldn4tm1.1Jhou,Tg(Aqp2-cre)1Dek/0
Genetic Background: B6.Cg-Cldn4tm1.1Jhou Tg(Aqp2-cre)1Dek

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Atoh7tm2Gan/Atoh7tm2Gan
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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