ENSMUSG00000014776


Mus musculus

Features
Gene ID: ENSMUSG00000014776
  
Biological name :Nol3
  
Synonyms : Nol3 / Nucleolar protein 3 / Q9D1X0
  
Possible biological names infered from orthology : O60936
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105276140
Gene end: 105281939
  
Corresponding Affymetrix probe sets: 10574676 (MoGene1.0st)   1444786_at (Mouse Genome 430 2.0 Array)   1451503_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014920
NCBI entrez gene - 78688     See in Manteia.
MGI - MGI:1925938
RefSeq - XM_006531503
RefSeq - NM_030152
RefSeq Peptide - NP_084428
swissprot - Q53YU5
swissprot - Q9D1X0
Ensembl - ENSMUSG00000014776
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOL3ENSG00000140939Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0006376 mRNA splice site selection IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010659 cardiac muscle cell apoptotic process IMP
 biological_processGO:0010664 negative regulation of striated muscle cell apoptotic process IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0014736 negative regulation of muscle atrophy IMP
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0014876 response to injury involved in regulation of muscle adaptation IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0060547 negative regulation of necrotic cell death IMP
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process IMP
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISS
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016528 sarcoplasm IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005123 death receptor binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035877 death effector domain binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0089720 caspase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6NTac

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0003547 abnormal pulmonary pressure "altered tension of the blood within the pulmonary arteries" [J:54986, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6NTac

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6NTac

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6NTac

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0005629 abnormal lung weight "any change from the normal state in the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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