ENSMUSG00000014850


Mus musculus

Features
Gene ID: ENSMUSG00000014850
  
Biological name :Msh3
  
Synonyms : Msh3 / mutS homolog 3
  
Possible biological names infered from orthology : P20585
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 92211872
Gene end: 92355003
  
Corresponding Affymetrix probe sets: 10411019 (MoGene1.0st)   1422261_a_at (Mouse Genome 430 2.0 Array)   1424166_at (Mouse Genome 430 2.0 Array)   1430643_at (Mouse Genome 430 2.0 Array)   1446511_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022220
Ensembl peptide - ENSMUSP00000141163
Ensembl peptide - ENSMUSP00000141158
Ensembl peptide - ENSMUSP00000140659
Ensembl peptide - ENSMUSP00000140402
Ensembl peptide - ENSMUSP00000140002
Ensembl peptide - ENSMUSP00000139622
Ensembl peptide - ENSMUSP00000139620
NCBI entrez gene - 17686     See in Manteia.
MGI - MGI:109519
RefSeq - XM_017315413
RefSeq - NM_001311120
RefSeq - NM_010829
RefSeq - XM_006517542
RefSeq - XM_006517543
RefSeq - XM_006517547
RefSeq - XM_017315412
RefSeq Peptide - NP_034959
RefSeq Peptide - NP_001298049
swissprot - A0A087WSR8
swissprot - A0A087WRJ5
swissprot - A0A087WQZ2
swissprot - A0A087WQ16
swissprot - A0A087WP45
swissprot - A0A087WSS2
swissprot - A0A087WP43
swissprot - E9QPY6
Ensembl - ENSMUSG00000014850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh3ENSDARG00000063276Danio rerio
 MSH3ENSGALG00000015589Gallus gallus
 MSH3ENSG00000113318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007695  DNA mismatch repair protein MutS-like, N-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR016151  DNA mismatch repair protein MutS, N-terminal
 IPR017261  DNA mismatch repair protein MutS/MSH
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036187  DNA mismatch repair protein MutS, core domain superfamily
 IPR036678  MutS, connector domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0043570 maintenance of DNA repeat elements IEA
 biological_processGO:0045910 negative regulation of DNA recombination IEA
 biological_processGO:0051096 positive regulation of helicase activity IEA
 cellular_componentGO:0032302 MutSbeta complex IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030983 mismatched DNA binding IEA
 molecular_functionGO:0032139 dinucleotide insertion or deletion binding IEA
 molecular_functionGO:0032142 single guanine insertion binding IEA
 molecular_functionGO:0032181 dinucleotide repeat insertion binding IEA


Pathways (from Reactome)
Pathway description
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh3tm1Rak/Msh3tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh3tm1Rak/Msh3tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Msh3tm1Htr/Msh3tm1Htr,Msh6tm1Htr/Msh6tm1Htr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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