ENSMUSG00000015342


Mus musculus

Features
Gene ID: ENSMUSG00000015342
  
Biological name :Xk
  
Synonyms : Q9QXY7 / Xk / X-linked Kx blood group
  
Possible biological names infered from orthology : P51811
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 9272756
Gene end: 9313250
  
Corresponding Affymetrix probe sets: 10598586 (MoGene1.0st)   1450189_at (Mouse Genome 430 2.0 Array)   1453866_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015486
NCBI entrez gene - 22439     See in Manteia.
MGI - MGI:103569
RefSeq - NM_023500
RefSeq Peptide - NP_075989
swissprot - Q059K7
swissprot - Q9QXY7
Ensembl - ENSMUSG00000015342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xkENSDARG00000056618Danio rerio
 XKENSGALG00000016262Gallus gallus
 XKENSG00000047597Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Xkrx / Q5GH68 / X-linked Kx blood group related, X-linked / Q6PP77* / XK related, X-linked*ENSMUSG0000003125839


Protein motifs (from Interpro)
Interpro ID Name
 IPR018629  XK-related protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IGI
 biological_processGO:0008361 regulation of cell size IGI
 biological_processGO:0010961 cellular magnesium ion homeostasis IGI
 biological_processGO:0031133 regulation of axon diameter IGI
 biological_processGO:0042552 myelination IMP
 biological_processGO:0048741 skeletal muscle fiber development IGI
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1)1Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ncoa5tm1Hxia/Ncoa5+
Genetic Background: C.129(B6)-Ncoa5tm1Hxia

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1)1Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0010738 abnormal internode morphology "any structrual anomaly of the intervening axon segment that is located between the juxtaparanodes and is surrounded by a single compact myelin sheath" [PMID:18929652]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0011730 increased myelin sheath thickness "increase in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
Show

Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

Allelic Composition: Xktm1Ariv/Xktm1Ariv
Genetic Background: B6.Cg-Xktm1Ariv

 MP:0011913 abnormal reticulocyte cell number "altered number of immature (nucleated) erythrocytes" [MPD:Molly]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

 MP:0012365 increased erythrocyte sodium level "increase in the amount in red blood cells of sodium" [MPD:Molly]
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Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

 MP:0012368 increased erythrocyte magnesium level "increase in the amount in red blood cells of magnesium" [MPD:Molly]
Show

Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1)1Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

 MP:0012372 abnormal erythrocyte ion content "abnormal quantity in red blood cells of atoms carrying an electric charge" [MPD:Molly]
Show

Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1)1Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

Allelic Composition: Keltm1Slee/Keltm1Slee,Xktm1Ariv/Y
Genetic Background: B6.Cg-Keltm1Slee Xktm1Ariv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029866 Kel / Q9EQF2 / Kell blood group glycoprotein homolog / P23276* / Kell blood group, metallo-endopeptidase*  / complex
 ENSMUSG00000027524 Edn3 / P48299 / Endothelin-3 / P14138*  / reaction






 

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