ENSMUSG00000015396


Mus musculus

Features
Gene ID: ENSMUSG00000015396
  
Biological name :Cd83
  
Synonyms : Cd83 / CD83 antigen / O88324
  
Possible biological names infered from orthology : CD83 molecule / Q01151
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A4
Gene start: 43784775
Gene end: 43803132
  
Corresponding Affymetrix probe sets: 10404840 (MoGene1.0st)   1416111_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015540
NCBI entrez gene - 12522     See in Manteia.
MGI - MGI:1328316
RefSeq - NM_009856
RefSeq - NM_001289915
RefSeq Peptide - NP_001276844
RefSeq Peptide - NP_033986
swissprot - O88324
Ensembl - ENSMUSG00000015396
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD83ENSGALG00000046032Gallus gallus
 CD83ENSG00000112149Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IBA
 biological_processGO:0006959 humoral immune response IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0014070 response to organic cyclic compound IMP
 biological_processGO:0032713 negative regulation of interleukin-4 production IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ey2/ey2+,Raxey1/Rax+
Genetic Background: involves: ZRDCT/Ch

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd83lcd4/Cd83lcd4
Genetic Background: involves: C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd83anu/Cd83anu
Genetic Background: involves: C57BL/6JAnu * CBA/CaJAnu

Allelic Composition: Cd83tm1.1Lnjt/Cd83tm1.1Lnjt
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Cd83tm1.1Lnjt/Cd83tm1.1Lnjt,March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd83lcd4/Cd83lcd4
Genetic Background: involves: C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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