Manteia - Molecule gene

ENSMUSG00000015536

Mus musculus

Features

Gene ID:	ENSMUSG00000015536

Biological name :	Mocs2

Synonyms :	Mocs2 / molybdenum cofactor synthesis 2

Possible biological names infered from orthology :	O96007 / O96033

Species:	Mus musculus

Chr. number:	13
Strand:	1
Band:	D2.2
Gene start:	114818236
Gene end:	114832275

Corresponding Affymetrix probe sets:	10407307 (MoGene1.0st) 1424309_a_at (Mouse Genome 430 2.0 Array) 1424310_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000139064 Ensembl peptide - ENSMUSP00000139355 Ensembl peptide - ENSMUSP00000139298 Ensembl peptide - ENSMUSP00000139285 Ensembl peptide - ENSMUSP00000015680 Ensembl peptide - ENSMUSP00000125797 Ensembl peptide - ENSMUSP00000128965 Ensembl peptide - ENSMUSP00000129021 Ensembl peptide - ENSMUSP00000131816 Ensembl peptide - ENSMUSP00000133069 Ensembl peptide - ENSMUSP00000138856 Ensembl peptide - ENSMUSP00000138936 Ensembl peptide - ENSMUSP00000139011 NCBI entrez gene - 17434 See in Manteia. MGI - MGI:1336894 RefSeq - NM_001113374 RefSeq - NM_001113375 RefSeq - NM_013826 RefSeq Peptide - NP_038854 RefSeq Peptide - NP_001106845 RefSeq Peptide - NP_001106846 swissprot - V9GX15 swissprot - E9PUX1 swissprot - A0A0R4J206 swissprot - F6ZGI7 swissprot - E9PVP5 Ensembl - ENSMUSG00000015536

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mocs2	ENSDARG00000077202	Danio rerio
MOCS2	ENSGALG00000014906	Gallus gallus
MOCS2	ENSG00000164172	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003448	Molybdopterin biosynthesis MoaE
IPR003749	Sulfur carrier ThiS/MoaD-like
IPR010034	Molybdopterin converting factor, subunit 1
IPR012675	Beta-grasp domain superfamily
IPR016155	Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
IPR028887	Molybdopterin synthase sulfur carrier subunit
IPR028888	Molybdopterin synthase catalytic subunit, eukaryotes
IPR036563	Molybdopterin biosynthesis MoaE subunit superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0016607	nuclear speck	IEA
cellular_component	GO:0019008	molybdopterin synthase complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0030366	molybdopterin synthase activity	IEA

Pathways (from Reactome)

Pathway description

Molybdenum cofactor biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000315	hemoglobinuria	"the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000746	weakness	"state of being infirm or less strong than littermates" [J:45400]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001195	flaky skin	"shedding scales on the skin " [J:56641]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001274	curly vibrissae	"whiskers twisted into coils or spirals" [J:47620]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002098	abnormal vibrissae morphology	"irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002708	kidney stones	"calculi occurring in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N Allelic Composition: Mocs2^{tm1(KOMP)Vlcg}/Mocs2⁺ Genetic Background: involves: C57BL/6NTac
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0003622	incomplete emptying of bladder	"upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0004194	abnormal kidney pelvis morphology	"any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0008822	decreased blood uric acid level	"reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0009552	urinary bladder obstruction	"any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Mmp9^{tm1b(EUCOMM)Wtsi}/Mmp9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Mmp9^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011419	erythrocyturia	"presence of red blood cells in the urine" [MGI:anna]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011424	decreased urine uric acid level	"abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011625	cystolithiasis	"caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011887	decreased circulating lipase level	"reduced blood level of lipase in the blood, in particular the serum" [MGI:csmith]	Show Allelic Composition: Mmp9^{tm1b(EUCOMM)Wtsi}/Mmp9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Mmp9^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011968	decreased threshold for auditory brainstem response	"reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]	Show Allelic Composition: Mmp9^{tm1b(EUCOMM)Wtsi}/Mmp9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Mmp9^{tm1b(EUCOMM)Wtsi}/Ics
MP:0020400	cystinuria	"excretion of excessive amounts of cystine in the urine" [HP:0003131]	Show Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr