ENSMUSG00000015804


Mus musculus

Features
Gene ID: ENSMUSG00000015804
  
Biological name :Med28
  
Synonyms : Med28 / Mediator of RNA polymerase II transcription subunit 28 / Q920D3
  
Possible biological names infered from orthology : mediator complex subunit 28 / Q9H204
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B3
Gene start: 45520229
Gene end: 45529276
  
Corresponding Affymetrix probe sets: 10521725 (MoGene1.0st)   1416508_at (Mouse Genome 430 2.0 Array)   1448374_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112418
Ensembl peptide - ENSMUSP00000115882
Ensembl peptide - ENSMUSP00000113027
NCBI entrez gene - 66999     See in Manteia.
MGI - MGI:1914249
RefSeq - NM_025895
RefSeq Peptide - NP_080171
swissprot - D3Z7D6
swissprot - D3YWT4
swissprot - Q920D3
Ensembl - ENSMUSG00000015804
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med28ENSDARG00000037410Danio rerio
 MED28ENSGALG00000007138Gallus gallus
 MED28ENSG00000118579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021640  Mediator complex, subunit Med28


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016592 mediator complex IDA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
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Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
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Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
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Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Marveld2tm1b(EUCOMM)Wtsi/Marveld2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Marveld2tm1b(EUCOMM)Wtsi/H

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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