ENSMUSG00000016239


Mus musculus

Features
Gene ID: ENSMUSG00000016239
  
Biological name :Lonrf3
  
Synonyms : LON peptidase N-terminal domain and RING finger protein 3 / Lonrf3 / Q9D4H7
  
Possible biological names infered from orthology : LON peptidase N-terminal domain and ring finger 3 / Q496Y0
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A3.3
Gene start: 36328353
Gene end: 36362341
  
Corresponding Affymetrix probe sets: 10599192 (MoGene1.0st)   1429863_at (Mouse Genome 430 2.0 Array)   1436200_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118175
Ensembl peptide - ENSMUSP00000016383
NCBI entrez gene - 74365     See in Manteia.
MGI - MGI:1921615
RefSeq - NM_028894
RefSeq - XM_006541404
RefSeq Peptide - NP_083170
swissprot - A2A3U8
swissprot - Q9D4H7
Ensembl - ENSMUSG00000016239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LONRF3ENSGALG00000008860Gallus gallus
 LONRF3ENSG00000175556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lonrf1 / LON peptidase N-terminal domain and ring finger 1 / Q17RB8*ENSMUSG0000003963339
Lonrf2 / LON peptidase N-terminal domain and ring finger 2 / Q1L5Z9*ENSMUSG0000004881425


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003111  Lon, substrate-binding domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015947  PUA-like superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019734  Tetratricopeptide repeat
 IPR027370  RING-type zinc-finger, LisH dimerisation motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005622 intracellular IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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