ENSMUSG00000016758


Mus musculus

Features
Gene ID: ENSMUSG00000016758
  
Biological name :Bik
  
Synonyms : Bcl-2-interacting killer / Bik / O70337
  
Possible biological names infered from orthology : Q13323
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 83526862
Gene end: 83544634
  
Corresponding Affymetrix probe sets: 10425801 (MoGene1.0st)   1420362_a_at (Mouse Genome 430 2.0 Array)   1420363_at (Mouse Genome 430 2.0 Array)   1449836_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016902
Ensembl peptide - ENSMUSP00000155083
Ensembl peptide - ENSMUSP00000155439
Ensembl peptide - ENSMUSP00000155777
NCBI entrez gene - 12124     See in Manteia.
MGI - MGI:1206591
RefSeq - XM_006520357
RefSeq - NM_007546
RefSeq - XM_006520355
RefSeq - XM_006520356
RefSeq - XM_006520353
RefSeq - XM_006520354
RefSeq Peptide - NP_031572
swissprot - O70337
Ensembl - ENSMUSG00000016758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BIKENSG00000100290Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024579  Bcl-2-interacting killer


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0032464 positive regulation of protein homooligomerization ISO
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005740 mitochondrial envelope IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051400 BH domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129S1-Bcl2l11tm1.1Ast

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2tm1Dlo/Bcl2tm1Dlo,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2tm1Dlo Biktm1Ast

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Biktm1Ast/Biktm1Ast
Genetic Background: B6.Cg-Bcl2l11tm1.1Ast Biktm1Ast

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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