ENSMUSG00000017002


Mus musculus

Features
Gene ID: ENSMUSG00000017002
  
Biological name :Slpi
  
Synonyms : P97430 / secretory leukocyte peptidase inhibitor / Slpi
  
Possible biological names infered from orthology : P03973
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 164354070
Gene end: 164389095
  
Corresponding Affymetrix probe sets: 10489463 (MoGene1.0st)   1448377_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104992
Ensembl peptide - ENSMUSP00000129629
Ensembl peptide - ENSMUSP00000128025
NCBI entrez gene - 20568     See in Manteia.
MGI - MGI:109297
RefSeq - NM_011414
RefSeq Peptide - NP_035544
swissprot - E9Q4A3
swissprot - E9Q748
swissprot - P97430
swissprot - Q548X8
Ensembl - ENSMUSG00000017002
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLPIENSG00000124107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008197  WAP-type "four-disulfide core" domain
 IPR036645  Elafin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0035821 modification of morphology or physiology of other organism IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045087 innate immune response IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tubb1tm1Shiv/Tubb1tm1Shiv
Genetic Background: Not Specified

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv

 MP:0008837 increased transforming growth factor level "greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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