ENSMUSG00000017550


Mus musculus

Features
Gene ID: ENSMUSG00000017550
  
Biological name :Atad5
  
Synonyms : Atad5 / ATPase family AAA domain-containing protein 5 / Q4QY64
  
Possible biological names infered from orthology : ATPase family, AAA domain containing 5 / Q96QE3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 80089400
Gene end: 80135794
  
Corresponding Affymetrix probe sets: 10379363 (MoGene1.0st)   1435597_at (Mouse Genome 430 2.0 Array)   1457565_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017694
Ensembl peptide - ENSMUSP00000103874
NCBI entrez gene - 237877     See in Manteia.
MGI - MGI:2442925
RefSeq - XM_017314529
RefSeq - NM_001029856
RefSeq - XM_011248989
RefSeq - XM_006533232
RefSeq - XM_006533233
RefSeq - XM_006533234
RefSeq Peptide - NP_001025027
swissprot - Z4YKQ9
swissprot - Q4QY64
Ensembl - ENSMUSG00000017550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atad5aENSDARG00000070568Danio rerio
 ATAD5ENSGALG00000003294Gallus gallus
 ATAD5ENSG00000176208Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002377 immunoglobulin production IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IMP
 biological_processGO:1901990 regulation of mitotic cell cycle phase transition IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0009591 liver adenocarcinoma "malignant neoplasm of epithelial cells in the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0010288 increased gland tumor incidence "greater than the expected number of tumors originating in a gland in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0010367 increased spindle cell carcinoma incidence "greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0014128 increased Harderian gland adenocarcinoma incidence "greater than the expected number of a malignant neoplasm of acinar epithelial cells in the Harderian gland, occurring in a specific population in a given time period; these usually are larger than adenomas and may cause facial selling and/or exophthalmos; they are highly cellular and disorganized compared to adenomas, with piling up of pleomorphic cells; areas of medullary or solid growth patterns are common; there may necrosis or hemorrhage, invasion beyond the orbit, and distant metastasis to the lungs, local lymph nodes, thymus or liver" [ISBN:0080467717]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr