ENSMUSG00000017718


Mus musculus

Features
Gene ID: ENSMUSG00000017718
  
Biological name :Afmid
  
Synonyms : Afmid / Kynurenine formamidase / Q8K4H1
  
Possible biological names infered from orthology : arylformamidase / Q63HM1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 117825924
Gene end: 117839908
  
Corresponding Affymetrix probe sets: 10382985 (MoGene1.0st)   1428885_at (Mouse Genome 430 2.0 Array)   1431722_a_at (Mouse Genome 430 2.0 Array)   1447638_at (Mouse Genome 430 2.0 Array)   1452944_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073102
Ensembl peptide - ENSMUSP00000119310
NCBI entrez gene - 71562     See in Manteia.
MGI - MGI:2448704
RefSeq - XM_011249269
RefSeq - NM_027827
RefSeq - XM_006534248
RefSeq - XM_006534249
RefSeq - XM_006534250
RefSeq - XM_006534245
RefSeq - XM_006534246
RefSeq - XM_006534247
RefSeq Peptide - NP_082103
swissprot - Q8K4H1
swissprot - B1AQL0
Ensembl - ENSMUSG00000017718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 afmidENSDARG00000099106Danio rerio
 AFMIDENSGALG00000000109Gallus gallus
 AFMIDENSG00000183077Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013094  Alpha/beta hydrolase fold-3
 IPR027519  Kynurenine formamidase, vertebrates/fungi-type
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006569 tryptophan catabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019441 tryptophan catabolic process to kynurenine IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004061 arylformamidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Afmidtm1b(EUCOMM)Wtsi/Afmid+
Genetic Background: C57BL/6N-Afmidtm1b(EUCOMM)Wtsi/H

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Afmidtm1b(EUCOMM)Wtsi/Afmid+
Genetic Background: C57BL/6N-Afmidtm1b(EUCOMM)Wtsi/H

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Afmidtm1b(EUCOMM)Wtsi/Afmid+
Genetic Background: C57BL/6N-Afmidtm1b(EUCOMM)Wtsi/H

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

Allelic Composition: Afmidtm1b(EUCOMM)Wtsi/Afmid+
Genetic Background: C57BL/6N-Afmidtm1b(EUCOMM)Wtsi/H

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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