ENSMUSG00000018914


Mus musculus

Features
Gene ID: ENSMUSG00000018914
  
Biological name :Il3
  
Synonyms : Il3 / interleukin 3 / P01586
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 54265303
Gene end: 54267277
  
Corresponding Affymetrix probe sets: 10385918 (MoGene1.0st)   1450566_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019058
NCBI entrez gene - 16187     See in Manteia.
MGI - MGI:96552
RefSeq - NM_010556
RefSeq Peptide - NP_034686
swissprot - P01586
swissprot - Q5SX77
Ensembl - ENSMUSG00000018914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002183  Interleukin-3
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0001660 fever generation IBA
 biological_processGO:0001666 response to hypoxia IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002763 positive regulation of myeloid leukocyte differentiation IGI
 biological_processGO:0006110 regulation of glycolytic process IGI
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010507 negative regulation of autophagy IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0030224 monocyte differentiation IGI
 biological_processGO:0033026 negative regulation of mast cell apoptotic process IDA
 biological_processGO:0033028 myeloid cell apoptotic process IDA
 biological_processGO:0035304 regulation of protein dephosphorylation IDA
 biological_processGO:0038156 interleukin-3-mediated signaling pathway IDA
 biological_processGO:0042976 activation of Janus kinase activity IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0070668 positive regulation of mast cell proliferation IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005135 interleukin-3 receptor binding IPI
 molecular_functionGO:0005149 interleukin-1 receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0003579 ovarian carcinoma 
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Il3tm1Glli/Il3tm1Glli,KitW/KitW-v
Genetic Background: involves: 129S2/SvPas * C57BL/6 * WB

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

Allelic Composition: Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Il3tm1Glli

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csf2tm1Mlg/Csf2tm1Mlg,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Mlg Il3tm1Glli

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Csf2tm1Dran Il3tm1Glli

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Il3tm1Glli/Il3tm1Glli
Genetic Background: C.129S2-Csf2tm1Dran Il3tm1Glli

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Il2rgtm1.1Flv/Il2rgtm1.1Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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