ENSMUSG00000018920


Mus musculus

Features
Gene ID: ENSMUSG00000018920
  
Biological name :Cxcl16
  
Synonyms : Cxcl16 / C-X-C motif chemokine 16 / Q8BSU2
  
Possible biological names infered from orthology : C-X-C motif chemokine ligand 16 / Q9H2A7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 70453983
Gene end: 70459984
  
Corresponding Affymetrix probe sets: 10387890 (MoGene1.0st)   1418718_at (Mouse Genome 430 2.0 Array)   1449195_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133513
Ensembl peptide - ENSMUSP00000019064
NCBI entrez gene - 66102     See in Manteia.
MGI - MGI:1932682
RefSeq - NM_023158
RefSeq - XM_006533920
RefSeq Peptide - NP_075647
swissprot - I7HIQ2
swissprot - A2CFE9
swissprot - Q8BSU2
Ensembl - ENSMUSG00000018920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCL16ENSG00000161921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026296  CXC chemokine 16


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010818 T cell chemotaxis IDA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0048247 lymphocyte chemotaxis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0042379 chemokine receptor binding IPI


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1rapl1tm1.1Hesk/Y
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048521 Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*  / reaction / complex






 

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