ENSMUSG00000019737


Mus musculus

Features
Gene ID: ENSMUSG00000019737
  
Biological name :Syne4
  
Synonyms : Nesprin-4 / Q8CII8 / Syne4
  
Possible biological names infered from orthology : Q8N205 / spectrin repeat containing nuclear envelope family member 4
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 30314807
Gene end: 30319046
  
Corresponding Affymetrix probe sets: 10551872 (MoGene1.0st)   1427175_at (Mouse Genome 430 2.0 Array)   1427176_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135844
Ensembl peptide - ENSMUSP00000135895
Ensembl peptide - ENSMUSP00000055874
Ensembl peptide - ENSMUSP00000135474
Ensembl peptide - ENSMUSP00000135558
Ensembl peptide - ENSMUSP00000135637
NCBI entrez gene - 233066     See in Manteia.
MGI - MGI:2141950
RefSeq - NM_001290565
RefSeq - NM_153577
RefSeq Peptide - NP_001277494
RefSeq Peptide - NP_705805
swissprot - Q8CII8
swissprot - H3BKP9
swissprot - H3BKW7
swissprot - H3BL35
swissprot - H3BLM5
swissprot - H3BLS3
Ensembl - ENSMUSG00000019737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYNE4ENSG00000181392Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012315  KASH domain
 IPR030268  Nesprin-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031309 integral component of nuclear outer membrane IDA
 cellular_componentGO:0034993 meiotic nuclear membrane microtubule tethering complex IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr