ENSMUSG00000019782


Mus musculus

Features
Gene ID: ENSMUSG00000019782
  
Biological name :Rwdd1
  
Synonyms : Q9CQK7 / Rwdd1 / RWD domain-containing protein 1
  
Possible biological names infered from orthology : Q9H446 / RWD domain containing 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B1
Gene start: 33996555
Gene end: 34019624
  
Corresponding Affymetrix probe sets: 10368630 (MoGene1.0st)   1427913_at (Mouse Genome 430 2.0 Array)   1454241_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019917
NCBI entrez gene - 66521     See in Manteia.
MGI - MGI:1913771
RefSeq - NM_025614
RefSeq Peptide - NP_079890
swissprot - Q9CQK7
Ensembl - ENSMUSG00000019782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rwdd1ENSDARG00000015930Danio rerio
 RWDD1ENSGALG00000014953Gallus gallus
 RWDD1ENSG00000111832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006575  RWD domain
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR032378  ZC3H15/TMA46 family, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002181 cytoplasmic translation IBA
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0030521 androgen receptor signaling pathway IMP
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0071394 cellular response to testosterone stimulus IMP
 biological_processGO:2000825 positive regulation of androgen receptor activity IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005844 polysome IBA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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