ENSMUSG00000019842


Mus musculus

Features
Gene ID: ENSMUSG00000019842
  
Biological name :Traf3ip2
  
Synonyms : TRAF3 interacting protein 2 / Traf3ip2
  
Possible biological names infered from orthology : O43734
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B1
Gene start: 39612934
Gene end: 39655307
  
Corresponding Affymetrix probe sets: 10362615 (MoGene1.0st)   1448508_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019987
NCBI entrez gene - 103213     See in Manteia.
MGI - MGI:2143599
RefSeq - NM_134000
RefSeq - XM_011243105
RefSeq Peptide - NP_598761
swissprot - Q8N7N6
Ensembl - ENSMUSG00000019842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704721.1ENSDARG00000113009Danio rerio
 traf3ip2lENSDARG00000091734Danio rerio
 TRAF3IP2ENSGALG00000015026Gallus gallus
 O43734ENSG00000056972Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013568  SEFIR domain
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001783 B cell apoptotic process IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0048305 immunoglobulin secretion IMP
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0000624 xerostomia "dryness of the mouth resulting from reduced salivary secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: A.KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: B6.KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: C.KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: AK.KOR-Traf3ip2adjm

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Barx2tm1Rsd/Barx2tm1Rsd,Dmdmdx/Dmdmdx
Genetic Background: involves: 129 * C57BL/6 * C57BL/10ScSn

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw
Genetic Background: involves: C57BL/6

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0002360 abnormal spleen B cell corona morphology "anomalous structure of the area of the splenic white pulp dominated by B lymphocyte follicles " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: A.KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: B6.KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: C.KOR-Traf3ip2adjm

Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: AK.KOR-Traf3ip2adjm

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0003746 stomatitis "inflammation of the mucous lining of the mouth" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0008121 increased myeloid dendritic cell number "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0
Genetic Background: involves: 129/Sv * BALB/c

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0008188 abnormal transitional stage B cell morphology "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0008879 submandibular gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0008896 increased IgG2c level "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

 MP:0009521 increased submandibular gland size "increased size of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Traf3ip2adjm/Traf3ip2adjm
Genetic Background: KOR-Traf3ip2adjm

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0013367 parotid gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear " [MGI:Anna]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0013558 abnormal exocrine gland morphology "any structural anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, MGI:Anna]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: C.129-Traf3ip2tm1.1Lix

Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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