MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0000624 | xerostomia | "dryness of the mouth resulting from reduced salivary secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0000685 | abnormal immune system morphology | "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
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MP:0000688 | lymphoid hyperplasia | "increased cell number in lymphatic tissues" [J:62478] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
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MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c
Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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MP:0000693 | spleen hyperplasia | "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c
Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw Genetic Background: involves: C57BL/6
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: A.KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: B6.KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: C.KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: AK.KOR-Traf3ip2adjm
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MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw Genetic Background: involves: C57BL/6
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MP:0001337 | dry eyes | "absence of natural or normal moisture in the eye" [J:53284] |
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Allelic Composition: Barx2tm1Rsd/Barx2tm1Rsd,Dmdmdx/Dmdmdx Genetic Background: involves: 129 * C57BL/6 * C57BL/10ScSn
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MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
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MP:0001805 | decreased IgG | "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0001876 | decreased inflammatory response | "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw Genetic Background: involves: C57BL/6
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gprasp1tm1.1Jlw/Gprasp1tm1.1Jlw Genetic Background: involves: C57BL/6
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0002360 | abnormal spleen B cell corona morphology | "anomalous structure of the area of the splenic white pulp dominated by B lymphocyte follicles " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
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MP:0002405 | respiratory system inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
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MP:0002459 | abnormal B cell physiology | "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
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MP:0002461 | increased circulating immunoglobulin concentration | "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: A.KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: B6.KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: C.KOR-Traf3ip2adjm
Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: AK.KOR-Traf3ip2adjm
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MP:0002742 | enlarged submandibular lymph nodes | "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0002743 | glomerulonephritis | "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw Genetic Background: B6.Cg-Ppargtm1.1Auw
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MP:0003725 | increased autoantibody level | "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0003746 | stomatitis | "inflammation of the mucous lining of the mouth" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0003799 | impaired macrophage migration | "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw Genetic Background: B6.Cg-Ppargtm1.1Auw
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MP:0004762 | increased anti-double stranded DNA antibody level | "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0004771 | increased anti-single stranded DNA antibody level | "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
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MP:0004794 | increased anti-nuclear antigen antibody level | "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0004796 | increased anti-histone antibody level | "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0004801 | increased susceptibility to systemic lupus erythematosus | "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0004802 | decreased susceptibility to systemic lupus erythematosus | "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0004829 | increased anti-chromatin antibody level | "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0004952 | increased spleen weight | "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
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MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0005065 | abnormal neutrophil morphology | "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0005090 | increased double-negative T cells count | "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0005251 | blepharitis | "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0005351 | decreased susceptibility to autoimmune disorders | "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw Genetic Background: B6.Cg-Ppargtm1.1Auw
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MP:0008037 | abnormal T cell morphology | "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008049 | increased memory T cell number | "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008082 | increased single-positive T cell number | "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008097 | increased plasma cell number | "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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MP:0008102 | lymph node hyperplasia | "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0008121 | increased myeloid dendritic cell number | "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008126 | increased dendritic cell number | "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lat2tm1Mal/Lat2tm1Mal Genetic Background: involves: 129S2/SvPas
Allelic Composition: Traf3ip2tm1Lix/Traf3ip2tm1.1Lix,Tg(CD19-cre/ERT2)1Cgn/0 Genetic Background: involves: 129/Sv * BALB/c
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MP:0008173 | increased follicular B cell number | "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0008174 | decreased follicular B cell number | "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
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MP:0008177 | increased germinal center B cell number | "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2+ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
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MP:0008181 | increased marginal zone B cell number | "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0008188 | abnormal transitional stage B cell morphology | "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0008189 | increased transitional stage B cell number | "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c
Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0008190 | decreased transitional stage B cell number | "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
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MP:0008211 | decreased mature B cell number | "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc Genetic Background: involves: 129 * 129S2/SvPas * BALB/c
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MP:0008214 | increased immature B cell number | "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0008481 | increased spleen germinal center number | "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0008524 | increased plasmacytoid dendritic cell number | "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008542 | enlarged cervical lymph nodes | "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0008706 | decreased interleukin-6 secretion | "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw Genetic Background: B6.Cg-Ppargtm1.1Auw
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MP:0008719 | impaired neutrophil recruitment | "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw Genetic Background: B6.Cg-Ppargtm1.1Auw
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MP:0008723 | impaired eosinophil recruitment | "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw Genetic Background: B6.Cg-Ppargtm1.1Auw
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MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2+ Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm1Sbn/Traf3ip2tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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MP:0008879 | submandibular gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0008880 | lacrimal gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0008896 | increased IgG2c level | "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
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MP:0009521 | increased submandibular gland size | "increased size of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0010072 | increased pruritus | "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Traf3ip2adjm/Traf3ip2adjm Genetic Background: KOR-Traf3ip2adjm
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MP:0011320 | abnormal glomerular capillary morphology | "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0011427 | mesangial cell hyperplasia | "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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MP:0013367 | parotid gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear " [MGI:Anna] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0013558 | abnormal exocrine gland morphology | "any structural anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, MGI:Anna] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
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MP:0020519 | renal glomerular immunoglobulin deposits | "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926] |
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: C.129-Traf3ip2tm1.1Lix
Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
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