ENSMUSG00000020077


Mus musculus

Features
Gene ID: ENSMUSG00000020077
  
Biological name :Srgn
  
Synonyms : Mus musculus serglycin (Srgn), transcript variant 2, mRNA. / P13609 / Srgn
  
Possible biological names infered from orthology : P10124 / serglycin
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 62493833
Gene end: 62527451
  
Corresponding Affymetrix probe sets: 10369615 (MoGene1.0st)   1417426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020271
Ensembl peptide - ENSMUSP00000125385
Ensembl peptide - ENSMUSP00000125533
Ensembl peptide - ENSMUSP00000125622
Ensembl peptide - ENSMUSP00000124365
NCBI entrez gene - 19073     See in Manteia.
MGI - MGI:97756
RefSeq - XM_006513377
RefSeq - NM_001358965
RefSeq - NM_011157
RefSeq - XM_006513374
RefSeq - XM_006513375
RefSeq - XM_006513376
RefSeq Peptide - NP_001345894
RefSeq Peptide - NP_035287
swissprot - E0CZH1
swissprot - P13609
swissprot - E0CYA5
Ensembl - ENSMUSG00000020077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SRGNENSGALG00000004167Gallus gallus
 SRGNENSG00000122862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007455  Serglycin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway ISS
 biological_processGO:0016485 protein processing IDA
 biological_processGO:0030502 negative regulation of bone mineralization IBA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0033364 mast cell secretory granule organization IMP
 biological_processGO:0033371 T cell secretory granule organization IMP
 biological_processGO:0033373 maintenance of protease location in mast cell secretory granule IMP
 biological_processGO:0033382 maintenance of granzyme B location in T cell secretory granule IMP
 biological_processGO:0050710 negative regulation of cytokine secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0042629 mast cell granule IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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