ENSMUSG00000020101


Mus musculus

Features
Gene ID: ENSMUSG00000020101
  
Biological name :Vsir
  
Synonyms : Q9D659 / V-set immunoregulatory receptor / Vsir
  
Possible biological names infered from orthology : Q9H7M9
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 60346851
Gene end: 60372684
  
Corresponding Affymetrix probe sets: 10363445 (MoGene1.0st)   1416619_at (Mouse Genome 430 2.0 Array)   1448407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020301
Ensembl peptide - ENSMUSP00000127569
Ensembl peptide - ENSMUSP00000101100
Ensembl peptide - ENSMUSP00000101099
NCBI entrez gene - 74048     See in Manteia.
MGI - MGI:1921298
RefSeq - NM_028732
RefSeq - NM_001159572
RefSeq Peptide - NP_001153044
RefSeq Peptide - NP_083008
swissprot - Q9D659
swissprot - D3Z7B7
swissprot - A0A171EBK7
swissprot - E9Q251
Ensembl - ENSMUSG00000020101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vsirENSDARG00000068784Danio rerio
 VSIRENSGALG00000030179Gallus gallus
 VSIRENSG00000107738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002725 negative regulation of T cell cytokine production IDA
 biological_processGO:0030509 BMP signaling pathway IGI
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
 biological_processGO:2000738 positive regulation of stem cell differentiation IGI
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Cd274tm1Igu/Cd274tm1Igu,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0009148 pancreas necrosis "pathological cell death in the pancreas, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0010857 pulmonary necrosis "pathological cell death in the lung, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Pdcd1tm1Hon/Pdcd1tm1Hon,Vsirtm1Lex/Vsirtm1Lex
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr