ENSMUSG00000020125


Mus musculus

Features
Gene ID: ENSMUSG00000020125
  
Biological name :Elane
  
Synonyms : Elane / Neutrophil elastase / Q3UP87
  
Possible biological names infered from orthology : elastase, neutrophil expressed / P08246
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79886247
Gene end: 79888215
  
Corresponding Affymetrix probe sets: 10364535 (MoGene1.0st)   1422928_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038925
NCBI entrez gene - 50701     See in Manteia.
MGI - MGI:2679229
RefSeq - NM_015779
RefSeq Peptide - NP_056594
swissprot - Q3UP87
Ensembl - ENSMUSG00000020125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ELANEENSG00000197561Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prtn3 / proteinase 3 / P24158*ENSMUSG0000005772949


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001878 response to yeast IMP
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IDA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0002812 biosynthetic process of antibacterial peptides active against Gram-negative bacteria IEA
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045079 negative regulation of chemokine biosynthetic process IEA
 biological_processGO:0045415 negative regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050778 positive regulation of immune response IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0070945 neutrophil mediated killing of gram-negative bacterium IEA
 biological_processGO:0070947 neutrophil mediated killing of fungus IMP
 biological_processGO:1903238 positive regulation of leukocyte tethering or rolling IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019955 cytokine binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Neutrophil degranulation
Antimicrobial peptides
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: 129X1/SvJ-Elanetm1Sds

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: 129X1/SvJ-Elanetm1Sds

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Mus81tm1Raz/Mus81+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Plcg2M2Btlr/Plcg2+
Genetic Background: C57BL/6J-Plcg2M2Btlr

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: 129X1/SvJ-Elanetm1Sds

Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: B6.129X1-Elanetm1Sds

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: 129X1/SvJ-Elanetm1Sds

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: 129X1/SvJ-Elanetm1Sds

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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