ENSMUSG00000020193


Mus musculus

Features
Gene ID: ENSMUSG00000020193
  
Biological name :Zpbp
  
Synonyms : zona pellucida binding protein / Zpbp
  
Possible biological names infered from orthology : Q9BS86
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 11279626
Gene end: 11462408
  
Corresponding Affymetrix probe sets: 10384352 (MoGene1.0st)   1450751_at (Mouse Genome 430 2.0 Array)   1453992_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020413
NCBI entrez gene - 53604     See in Manteia.
MGI - MGI:1855701
RefSeq - XM_006514755
RefSeq - NM_001185153
RefSeq - NM_015785
RefSeq Peptide - NP_056600
RefSeq Peptide - NP_001172082
swissprot - Q5NC84
Ensembl - ENSMUSG00000020193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZPBPENSGALG00000013083Gallus gallus
 ZPBPENSG00000042813Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zpbp2 / Q6X786 / zona pellucida binding protein 2 / Q6X784*ENSMUSG0000001719525


Protein motifs (from Interpro)
Interpro ID Name
 IPR010857  Zona-pellucida-binding
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbp+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Zpbptm1Zuk/Zpbp+,Zpbp2tm1Zuk/Zpbp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Zpbptm1Zuk/Zpbptm1Zuk,Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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