ENSMUSG00000020267


Mus musculus

Features
Gene ID: ENSMUSG00000020267
  
Biological name :Hint1
  
Synonyms : Hint1 / Histidine triad nucleotide-binding protein 1 / P70349
  
Possible biological names infered from orthology : P49773
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 54866383
Gene end: 54870501
  
Corresponding Affymetrix probe sets: 10376196 (MoGene1.0st)   1424017_a_at (Mouse Genome 430 2.0 Array)   1424018_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114037
Ensembl peptide - ENSMUSP00000020504
NCBI entrez gene - 15254     See in Manteia.
MGI - MGI:1321133
RefSeq - NM_008248
RefSeq Peptide - NP_032274
swissprot - B0R1E3
swissprot - P70349
Ensembl - ENSMUSG00000020267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hint1ENSDARG00000103824Danio rerio
 HINT1ZENSGALG00000000428Gallus gallus
 HINT1ENSG00000169567Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hint2 / Q9D0S9 / histidine triad nucleotide binding protein 2 / Q9BX68*ENSMUSG0000002847060


Protein motifs (from Interpro)
Interpro ID Name
 IPR001310  Histidine triad (HIT) protein
 IPR011146  HIT-like domain
 IPR019808  Histidine triad, conserved site
 IPR036265  HIT-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009154 purine ribonucleotide catabolic process IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016787 hydrolase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Hint1tm1Tpm/Hint1tm1Tpm
Genetic Background: Not Specified

Allelic Composition: Fhittm1Hbn/Fhittm1Hbn,Hint1tm1.1Tpm/Hint1+
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Hint1tm1Tpm/Hint1tm1Tpm
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hellstm1a(EUCOMM)Wtsi/Hellstm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hellstm1a(EUCOMM)Wtsi/Ieg

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Hellstm1a(EUCOMM)Wtsi/Hellstm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hellstm1a(EUCOMM)Wtsi/Ieg

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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