ENSMUSG00000020303


Mus musculus

Features
Gene ID: ENSMUSG00000020303
  
Biological name :Stc2
  
Synonyms : O88452 / stanniocalcin 2 / Stc2
  
Possible biological names infered from orthology : O76061
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 31357307
Gene end: 31370074
  
Corresponding Affymetrix probe sets: 10384961 (MoGene1.0st)   1419503_at (Mouse Genome 430 2.0 Array)   1445186_at (Mouse Genome 430 2.0 Array)   1449484_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020546
NCBI entrez gene - 20856     See in Manteia.
MGI - MGI:1316731
RefSeq - NM_011491
RefSeq Peptide - NP_035621
swissprot - O88452
swissprot - Q5SS12
Ensembl - ENSMUSG00000020303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stc2aENSDARG00000056680Danio rerio
 stc2bENSDARG00000102206Danio rerio
 STC2ENSGALG00000002893Gallus gallus
 STC2ENSG00000113739Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stc1 / O55183 / stanniocalcin 1 / P52823*ENSMUSG0000001481325


Protein motifs (from Interpro)
Interpro ID Name
 IPR004978  Stanniocalcin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0040015 negative regulation of multicellular organism growth IMP
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0046885 regulation of hormone biosynthetic process IEA
 biological_processGO:0055074 calcium ion homeostasis IGI
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:2000118 regulation of sodium-dependent phosphate transport ISO
 biological_processGO:2001256 regulation of store-operated calcium entry IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000202 abnormal circulating alkaline phosphatase level "anomalous concentration in the blood of this enzyme, which hydrolyzes orthophosphoric monoesters; low levels are seen in cases of hypophosphatasia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

Allelic Composition: Stc1tm1Rred/Stc1tm1Rred,Stc2tm1Rred/Stc2tm1Rred
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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