ENSMUSG00000020308


Mus musculus

Features
Gene ID: ENSMUSG00000020308
  
Biological name :Tpgs1
  
Synonyms : Q99MS8 / Tpgs1 / tubulin polyglutamylase complex subunit 1
  
Possible biological names infered from orthology : Q6ZTW0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79669369
Gene end: 79676127
  
Corresponding Affymetrix probe sets: 10364451 (MoGene1.0st)   1451981_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020552
NCBI entrez gene - 110012     See in Manteia.
MGI - MGI:106618
RefSeq - NM_148934
RefSeq Peptide - NP_683736
swissprot - B2RRP1
swissprot - Q99MS8
Ensembl - ENSMUSG00000020308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:92789ENSDARG00000027547Danio rerio
 TPGS1ENSGALG00000026780Gallus gallus
 TPGS1ENSG00000141933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0018095 protein polyglutamylation TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0051648 vesicle localization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IMP
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0070740 tubulin-glutamic acid ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001355 submission towards males "no domineering, assault posture nor hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9, J:60896]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1etm1Hssh/Cacna1etm1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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