ENSMUSG00000020419


Mus musculus

Features
Gene ID: ENSMUSG00000020419
  
Biological name :Hormad2
  
Synonyms : Hormad2 / HORMA domain-containing protein 2 / Q5SQP1
  
Possible biological names infered from orthology : HORMA domain containing 2 / Q8N7B1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 4345814
Gene end: 4441105
  
Corresponding Affymetrix probe sets: 10383853 (MoGene1.0st)   1454052_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020689
Ensembl peptide - ENSMUSP00000105574
Ensembl peptide - ENSMUSP00000105575
Ensembl peptide - ENSMUSP00000121715
NCBI entrez gene - 75828     See in Manteia.
MGI - MGI:1923078
RefSeq - XM_017314817
RefSeq - XM_011243777
RefSeq - XM_011243779
RefSeq - XM_011243780
RefSeq - XM_011243781
RefSeq - NM_029458
RefSeq Peptide - NP_083734
swissprot - H7BWX7
swissprot - B1ATD3
swissprot - Q5SQP1
Ensembl - ENSMUSG00000020419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HORMAD2ENSGALG00000008037Gallus gallus
 Q8N7B1ENSG00000176635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D5T7 / Hormad1 / HORMA domain-containing protein 1 / Q86X24* / HORMA domain containing 1*ENSMUSG0000002810947


Protein motifs (from Interpro)
Interpro ID Name
 IPR003511  HORMA domain
 IPR036570  HORMA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051177 meiotic sister chromatid cohesion IMP
 biological_processGO:0051321 meiotic cell cycle IEP
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hormad2tm1Kura/Hormad2+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura
Genetic Background: either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hormad2tm1Atot/Hormad2tm1Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura
Genetic Background: either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura
Genetic Background: either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura
Genetic Background: either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

Allelic Composition: Hormad2tm1Kura/Hormad2+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura
Genetic Background: either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hormad2tm1Kura/Hormad2+,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

Allelic Composition: Hormad2tm1Kura/Hormad2tm1Kura
Genetic Background: either: B6.Cg-Hormad2tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0008966 abnormal chiasmata formation "atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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